Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. (Q43002840)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578560%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

title

Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites (English)

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18 December 2019

2

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18 December 2019

Robert J Williams

series ordinal

3

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18 December 2019

4

Catherine Rice-Evans

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18 December 2019

1

Jeremy P E Spencer

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18 December 2019

language of work or name

English

0 references

publication date

1 May 2003

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18 December 2019

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18 December 2019

volume

372

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18 December 2019

issue

Pt 1

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18 December 2019

page(s)

173-181

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Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells

18 December 2019

cites work

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Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens

26 May 2018

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Effect of quercetin and its conjugated metabolite on the hydrogen peroxide-induced intracellular production of reactive oxygen species in mouse fibroblasts

26 May 2018

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Identification of o-quinone/quinone methide metabolites of quercetin in a cellular in vitro system.

26 May 2018

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Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin.

26 May 2018

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Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

26 May 2018

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Catechin metabolism: glutathione conjugate formation catalyzed by tyrosinase, peroxidase, and cytochrome p450.

26 May 2018

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Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation

26 May 2018

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Epicatechin and its in vivo metabolite, 3'-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation

26 May 2018

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Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms

26 May 2018

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Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation

26 May 2018

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Bioflavonoid quercetin inhibits mitosis and apoptosis of glomerular cells in vitro and in vivo

26 May 2018

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Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells

26 May 2018

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Dietary intake and bioavailability of polyphenols

26 May 2018

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Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts.

26 May 2018

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Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line

26 May 2018

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Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway

26 May 2018

1 reference

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Fate of the flavonoid quercetin in human cell lines: chemical instability and metabolism

26 May 2018

1 reference

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Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans

26 May 2018

1 reference

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Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species.

26 May 2018

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Biological reactivity of polyphenolic-glutathione conjugates

26 May 2018

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Quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: cooperative effects of ascorbic acid

26 May 2018

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Effect of quercetin on the growth of mouse fibroblast cells in vitro.

26 May 2018

1 reference

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Effect of superoxide dismutase on the autoxidation of hydroquinones formed during DT-diaphorase catalysis and glutathione nucleophilic addition

26 May 2018

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The ATP-dependent glutathione S-conjugate export pump

26 May 2018

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Mutagenicity of plant flavonoids: Structural requirements for mutagenic activity in Salmonella typhimurium

26 May 2018

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5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons

26 May 2018

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In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids

16 August 2018

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Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis

16 August 2018

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The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent

16 August 2018

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Structure activity relationships for the chemical behaviour and toxicity of electrophilic quinones/quinone methides

16 August 2018

1 reference

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Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223367

Quercetin modifies reactive oxygen levels but exerts only partial protection against oxidative stress within HL-60 cells

16 August 2018

1 reference

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Structure-activity study on the quinone/quinone methide chemistry of flavonoids

16 August 2018

1 reference

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Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223367

Brain mitochondria catalyze the oxidation of 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1) to intermediates that irreversibly inhibit complex I and scavenge glutathione: potential relevance to the pathogenes

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223367

Induction of apoptosis by quercetin: involvement of heat shock protein

16 August 2018

1 reference

12 December 2020

Superoxide-dependent depletion of reduced glutathione by L-DOPA and dopamine. Relevance to Parkinson's disease

1 reference

12 December 2020

Further insights into the influence of L-cysteine on the oxidation chemistry of dopamine: reaction pathways of potential relevance to Parkinson's disease

1 reference

12 December 2020

Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes

1 reference

12 December 2020

Two-electron electrochemical oxidation of quercetin and kaempferol changes only the flavonoid C-ring

1 reference

12 December 2020

Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product

1 reference

12 December 2020

The small intestine can both absorb and glucuronidate luminal flavonoids

1 reference

12 December 2020

The pharmacology and toxicology of polyphenolic-glutathione conjugates

1 reference

12 December 2020

Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells

1 reference

12 December 2020

Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin

1 reference

12 December 2020

Respective bioavailability of quercetin aglycone and its glycosides in a rat model

1 reference

12 December 2020

Metabolic fate of luteolin and its functional activity at focal site

1 reference

12 December 2020

Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20021972

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578560%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12578560%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

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