Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage (Q43002977)

12 November 2017

Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage (English)

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12 November 2017

4

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12 November 2017

Etienne Decroly

3

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author name string

Eric Bergeron

series ordinal

1

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PMCID

1223497

12 November 2017

Ajoy Basak

series ordinal

2

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PMCID

1223497

12 November 2017

language of work or name

English

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publication date

1 July 2003

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12 November 2017

10

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inferred from page(s)

published in

Biochemical Journal

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12 November 2017

373

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12 November 2017

475-484

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12 November 2017

Pt 2

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Structure-function analysis of the prosegment of the proprotein convertase PC5A.

12 November 2017

1 reference

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Integrins: bidirectional, allosteric signaling machines

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Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment

26 May 2018

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

26 May 2018

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Production, purification, and characterization of recombinant prohormone convertase 5 from baculovirus-infected insect cells

26 May 2018

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Molecular complexity and dynamics of cell-matrix adhesions

26 May 2018

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The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor

26 May 2018

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Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides

26 May 2018

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The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments

26 May 2018

1 reference

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26 May 2018

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Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

26 May 2018

1 reference

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Interaction of alpha4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro.

26 May 2018

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Biogenesis of alpha6beta4 integrin in a human colonic adenocarcinoma cell line involvement of calnexin

26 May 2018

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Ammonia inhibits neural cell adhesion molecule polysialylation in Chinese hamster ovary and small cell lung cancer cells.

26 May 2018

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Chinese hamster ovary cells expressing alpha4beta1 integrin stimulate osteoclast formation in vitro.

26 May 2018

1 reference

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The Notch1 receptor is cleaved constitutively by a furin-like convertase

26 May 2018

1 reference

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In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor

26 May 2018

1 reference

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Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

26 May 2018

1 reference

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Identification of the cleavage sites in the alpha6A integrin subunit: structural requirements for cleavage and functional analysis of the uncleaved alpha6Abeta1 integrin

26 May 2018

1 reference

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Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

26 May 2018

1 reference

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Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160

26 May 2018

1 reference

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Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

26 May 2018

1 reference

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Lack of integrin alpha-chain endoproteolytic cleavage in furin-deficient human colon adenocarcinoma cells LoVo

26 May 2018

1 reference

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Retrieval of TGN proteins from the cell surface requires endosomal acidification.

26 May 2018

1 reference

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26 May 2018

1 reference

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Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases

26 May 2018

1 reference

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A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells

26 May 2018

1 reference

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Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.

26 May 2018

1 reference

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Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development

26 May 2018

1 reference

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The pathophysiologic role of alpha 4 integrins in vivo

26 May 2018

1 reference

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Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin

26 May 2018

1 reference

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Structure of the integrin VLA-4 and its cell-cell and cell-matrix adhesion functions

26 May 2018

1 reference

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Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage

26 May 2018

1 reference

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Post-translational processing of the leukocyte integrin alpha 4 beta 1

26 May 2018

1 reference

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Mechanisms of pH regulation in the regulated secretory pathway

26 May 2018

1 reference

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Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization.

16 August 2018

1 reference

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Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.

16 August 2018

1 reference

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Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins.

16 August 2018

1 reference

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Specific cleavage of the alpha 4 integrin associated with activation of peripheral T lymphocytes.

16 August 2018

1 reference

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Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant

16 August 2018

1 reference

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Role of endoproteolytic processing in the adhesive and signaling functions of alphavbeta5 integrin

16 August 2018

1 reference

12 December 2020

Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway

1 reference

12 December 2020

Mechanism of acidification of the trans-Golgi network (TGN). In situ measurements of pH using retrieval of TGN38 and furin from the cell surface

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The interrelationship of alpha4 integrin and matrix metalloproteinase-2 in the pathogenesis of experimental autoimmune encephalomyelitis

1 reference

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Integrins and signal transduction

1 reference

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Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides

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Cleavage of proalbumin peptides by furin reveals unexpected restrictions at the P2 and P'1 sites

1 reference

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Identifiers

DOI

10.1042/BJ20021630

1 reference

12 November 2017

1 reference

12 November 2017

1 reference

PMCID

1223497