Probing cathepsin K activity with a selective substrate spanning its active site. (Q43003155)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12837132%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

Probing cathepsin K activity with a selective substrate spanning its active site (English)

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5 November 2019

5

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5 November 2019

author name string

Fabien Lecaille

1

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5 November 2019

Enrico Weidauer

2

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5 November 2019

Maria A Juliano

3

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5 November 2019

Dieter Brömme

4

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5 November 2019

language of work or name

English

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publication date

1 October 2003

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5 November 2019

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5 November 2019

volume

375

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5 November 2019

issue

Pt 2

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5 November 2019

page(s)

307-312

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Lysosomal cysteine proteases (cathepsins): promising drug targets.

5 November 2019

cites work

1 reference

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Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

26 May 2018

1 reference

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Expression of cathepsins B, H, K, L, and S during human fetal lung development

26 May 2018

1 reference

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Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K.

26 May 2018

1 reference

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Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Cathepsin K and the design of inhibitors of cathepsin K.

26 May 2018

1 reference

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Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones

26 May 2018

1 reference

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Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization

26 May 2018

1 reference

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Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization

26 May 2018

1 reference

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Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Design of potent and selective human cathepsin K inhibitors that span the active site

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Cysteine-proteinase-inhibiting function of T kininogen and of its proteolytic fragments

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Introduction of a cysteine protease active site into trypsin

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Identification of a 33-kilodalton immunodominant antigen of Trypanosoma congolense as a cysteine protease

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Cathepsin K mRNA and protein expression in prostate cancer progression

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Cathepsin K--a marker of macrophage differentiation?

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Subsite specificity of trypanosomal cathepsin L-like cysteine proteases. Probing the S2 pocket with phenylalanine-derived amino acids

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223680

Collagenolytic activity of cathepsin K is specifically modulated by cartilage-resident chondroitin sulfates

16 August 2018

1 reference

12 December 2020

Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group

1 reference

12 December 2020

The specificity of the S1' subsite of cysteine proteases

1 reference

12 December 2020

A comparison of the enzymatic properties of the major cysteine proteinases from Trypanosoma congolense and Trypanosoma cruzi

1 reference

12 December 2020

The collagenolytic activity of cathepsin K is unique among mammalian proteinases

1 reference

12 December 2020

Discrimination of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, and mammalian cathepsins B and L, by a pH-inducible fluorogenic substrate of trypanosomal cysteine proteinases

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20030468

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12837132%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12837132%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference