Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner (Q43008071)

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scientific article published on 31 July 2008

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English	Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner	scientific article published on 31 July 2008

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scholarly article

1 reference

Europe PubMed Central

12 November 2017

Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner (English)

1 reference

Europe PubMed Central

12 November 2017

Candece L Gladson

2

object named as

Candece L Gladson

1 reference

Europe PubMed Central

12 November 2017

author name string

Qiang Ding

1

1 reference

Europe PubMed Central

12 November 2017

Hongju Wu

3

1 reference

Europe PubMed Central

12 November 2017

Haurko Hayasaka

4

1 reference

Europe PubMed Central

12 November 2017

Mitchell A Olman

5

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Europe PubMed Central

12 November 2017

language of work or name

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publication date

31 July 2008

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Europe PubMed Central

12 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

12 November 2017

283

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Europe PubMed Central

12 November 2017

40

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Europe PubMed Central

12 November 2017

26839-26849

1 reference

Europe PubMed Central

12 November 2017

Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta

1 reference

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26 May 2018

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

1 reference

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26 May 2018

PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling

1 reference

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26 May 2018

The myofibroblast: one function, multiple origins

1 reference

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26 May 2018

Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene

1 reference

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Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells

1 reference

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Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis

1 reference

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Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

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Src protein tyrosine kinase family and acute inflammatory responses.

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FRNK, the autonomously expressed C-terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: analysis of expression in transgenic mice

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Tissue repair, contraction, and the myofibroblast

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p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain

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Tyrosine phosphorylation of the LDL receptor-related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation

1 reference

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FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?

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26 May 2018

Control of motile and invasive cell phenotypes by focal adhesion kinase.

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Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells

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Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis

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Focal adhesion kinase regulation of N-WASP subcellular localization and function

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The myofibroblast in wound healing and fibrocontractive diseases

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26 May 2018

Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts.

1 reference

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26 May 2018

Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling

1 reference

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26 May 2018

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

1 reference

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Focal adhesion kinase: the first ten years

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The myofibroblast in pulmonary fibrosis

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FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth

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Construction and characterization of adenovirus serotype 5 packaged by serotype 3 hexon

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Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.

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TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

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26 May 2018

The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

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TGF-beta1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion.

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Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

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Focal adhesion kinase is involved in mechanosensing during fibroblast migration

1 reference

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Alpha-smooth muscle actin expression upregulates fibroblast contractile activity

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Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells

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Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy

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Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouse

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Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway

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Role of Ras and Mapks in TGFbeta signaling

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Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase

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Fibrin fragment induction of plasminogen activator inhibitor transcription is mediated by activator protein-1 through a highly conserved element.

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Integrin signaling

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Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

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Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

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The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1.

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Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

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Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK

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Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase.

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https://pubmed.ncbi.nlm.nih.gov/18669633

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Identifiers

10.1074/JBC.M803645200

1 reference

Europe PubMed Central

12 November 2017

1 reference

Europe PubMed Central

12 November 2017

1 reference

Europe PubMed Central

12 November 2017

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