Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression. (Q43049709)

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4 February 2020

title

Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression (English)

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4 February 2020

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1

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4 February 2020

Florian W Kiefer

4

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4 February 2020

Angelika Neuhofer

5

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4 February 2020

Thomas M Stulnig

6

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4 February 2020

author name string

K Gollinger

2

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4 February 2020

E Kriehuber

3

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4 February 2020

language of work or name

English

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publication date

1 June 2010

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International Journal of Obesity

4 February 2020

published in

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4 February 2020

volume

34

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4 February 2020

issue

12

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4 February 2020

page(s)

1684-1694

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https://scigraph.springernature.com/pub.10.1038/ijo.2010.103

4 February 2020

exact match

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cites work

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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Alternative activation of macrophages

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Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes

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A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

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Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production.

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Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

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CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity.

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T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity

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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

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Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.

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Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

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Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected].

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Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

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Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations.

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Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice

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Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals

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Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy

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