Endogenous opioids: overview and current issues (Q43070748)

13 November 2017

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title

Endogenous opioids: overview and current issues (English)

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13 November 2017

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H Akil

1

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13 November 2017

C Owens

2

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13 November 2017

H Gutstein

3

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13 November 2017

L Taylor

4

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13 November 2017

E Curran

5

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13 November 2017

S Watson

6

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13 November 2017

1 June 1998

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Drug and Alcohol Dependence

13 November 2017

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13 November 2017

51

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13 November 2017

1-2

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13 November 2017

127-140

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Cloning of kappa opioid receptors: functional significance and future directions

13 November 2017

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https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

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https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Endogenous Opioids: Biology and Function

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Opiate binding properties of naturally occurring N- and C-Terminus modified beta-endorphins

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Beta-endorphin-(1-27) is a naturally occurring antagonist of the reinforcing effects of opioids.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Synthetic analgesics: stereochemical considerations

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Chromosomal localization of the delta opioid receptor gene to human 1p34.3-p36.1 and mouse 4D bands by in situ hybridization

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Diversity in function and regulation of MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Parallel signal processing among mammalian MAPKs

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Morphine activation of c-fos expression in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Local and distal effects induced by unilateral striatal application of opiates in the absence or in the presence of naloxone on the release of dopamine in both caudate nuclei and substantiae nigrae of the cat.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

How MAP kinases are regulated

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Controlling signaling with a specifically designed Gi-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Dopamine receptor mRNA expression patterns by opioid peptide cells in the nucleus accumbens of the rat: a double in situ hybridization study

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Cloning of a delta opioid receptor by functional expression

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Functional coupling of the delta-, mu-, and kappa-opioid receptors to mitogen-activated protein kinase and arachidonate release in Chinese hamster ovary cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Receptor-induced internalization of selective peptidic mu and delta opioid ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Dynorphin-(1-13), an extraordinarily potent opioid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

An Opiate Binding Site in the Rat Brain Is Highly Selective for 4,5-Epoxymorphinans

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Cyclic somatostatin octapeptide analogues with high affinity and selectivity toward mu opioid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Opioid effects on mitogen-activated protein kinase signaling cascades

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Specificity in the projection patterns of accumbal core and shell in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Transcriptional regulation by extracellular signals: mechanisms and specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

The distribution of enkephalin-immunoreactive cell bodies in the rat central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Morphine activates opioid receptors without causing their rapid internalization

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Agonists and antagonists bind to different domains of the cloned kappa opioid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

beta-endorphin is a potent analgesic agent

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Endogenous opioid peptides: multiple agonists and receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Common precursor to corticotropins and endorphins

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Kappa 1 receptor mRNA distribution in the rat CNS: comparison to kappa receptor binding and prodynorphin mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

mu-Opioid receptor mRNA expression in the rat CNS: comparison to mu-receptor binding

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Anatomy of CNS opioid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Site-directed mutagenesis of the human dopamine D2 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

A chimeric study of the molecular basis of affinity and selectivity of the kappa and the delta opioid receptors. Potential role of extracellular domains

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Mapping the receptor domains critical for the binding selectivity of delta-opioid receptor ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Cloning and pharmacological characterization of a rat kappa opioid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Cloning and expression of a cDNA for the rat kappa-opioid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered μ-opioid receptor agonist in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Evidence for two subtypes of δ opioid receptors in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Molecular mechanisms of drug addiction

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Under siege: The brain on opiates

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Molecular and cellular basis of addiction

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Primary structure and tissue distribution of the orphanin FQ precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Nocistatin, a peptide that blocks nociceptin action in pain transmission

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Cloning and expression of a cDNA encoding a mouse brain orphanin FQ/nociceptin precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Multiple morphine and enkephalin receptors: biochemical and pharmacological aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Kappa opioid receptors stimulate phosphoinositide turnover in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Opiate Receptor: Demonstration in Nervous Tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Functional analysis of cloned opioid receptors in transfected cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Properties of a kappa-opioid receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual G alpha subunit and is similar to that of other opioid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Selective receptors for β-endorphin on the rat vas deferens

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Molecular mechanism of opioid receptor selection

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

The MAPK signaling cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

A constitutively internalizing and recycling mutant of the mu-opioid receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Molecular mechanisms of drug reinforcement and addiction

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Opiate-dependent modulation of adenylate cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Neuroanatomical substrates mediating the aversive effects of D-1 dopamine receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Conditioning of opioid reinforcement: neuroanatomical and neurochemical substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Stereospecific Binding of the Potent Narcotic Analgesic [ 3 H]Etorphine to Rat-Brain Homogenate

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Cloning and pharmacological characterization of a rat mu opioid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

beta-Endorphin-(1-27) inhibits the spinal beta-endorphin-induced release of Met-enkephalin

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Protein kinase C involvement in homologous desensitization of delta-opioid receptor coupled to Gi1-phospholipase C activation in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

mu opiate receptor: cDNA cloning and expression

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Dynorphin immunocytochemical localization in brain and peripheral nervous system: preliminary studies

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Evidence for two separate opiate peptide neuronal systems

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Localization of the kappa opioid receptor gene to human chromosome band 8q11.2.

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

A potent and selective endogenous agonist for the mu-opiate receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Characterization of zeta (zeta): a new opioid receptor involved in growth

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

Ventral striatopallidal parts of the basal ganglia in the rat: I. Neurochemical compartmentation as reflected by the distributions of neurotensin and substance P immunoreactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0376-8716%2898%2900071-4

7 January 2021

10.1016/S0376-8716(98)00071-4

Identifiers

DOI

1 reference

13 November 2017

1 reference