Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model (Q43136005)

14 November 2017

Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model (English)

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14 November 2017

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David Baglietto-Vargas

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14 November 2017

7

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14 November 2017

Haley C Dunn

1

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14 November 2017

Rahasson R Ager

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14 November 2017

David Cheng

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14 November 2017

Masashi Kitazawa

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14 November 2017

David H Cribbs

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14 November 2017

1 January 2015

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Journal of Alzheimer's Disease

14 November 2017

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14 November 2017

43

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3

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14 November 2017

893-903

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describes a project that uses

14 November 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4319708/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

25 May 2018

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FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo .

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The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

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Modulation of amyloid-β production by leukotriene B4 via the γ-secretase pathway

25 May 2018

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The 12-15-lipoxygenase is a modulator of Alzheimer's-related tau pathology in vivo

25 May 2018

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Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice

25 May 2018

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Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model

25 May 2018

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Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury

25 May 2018

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Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model

25 May 2018

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Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells

25 May 2018

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Inflammation induced by infection potentiates tau pathological features in transgenic mice

25 May 2018

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Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase

25 May 2018

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Contribution of systemic inflammation to chronic neurodegeneration

25 May 2018

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Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase

25 May 2018

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Inflammation in neurodegenerative diseases

25 May 2018

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The role of tau in Alzheimer's disease and related disorders

25 May 2018

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Alternative activation of macrophages: mechanism and functions

25 May 2018

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25 May 2018

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Immune activation in brain aging and neurodegeneration: too much or too little?

25 May 2018

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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

25 May 2018

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5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease

25 May 2018

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Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways

25 May 2018

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Interleukin-1 mediates Alzheimer and Lewy body pathologies.

25 May 2018

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Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX

25 May 2018

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Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins

25 May 2018

1 reference

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Innate immunity and inflammation in ageing: a key for understanding age-related diseases

25 May 2018

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Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

25 May 2018

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What's in a picture? The temptation of image manipulation

25 May 2018

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12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress

25 May 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

25 May 2018

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Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

25 May 2018

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Inflammation in neurodegenerative disease--a double-edged sword

25 May 2018

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

25 May 2018

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Lipoxins: revelations on resolution

25 May 2018

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Tau filament formation in transgenic mice expressing P301L tau.

25 May 2018

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Putative role of neuronal 5-lipoxygenase in an aging brain.

25 May 2018

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The role of leukotrienes in inflammation

25 May 2018

1 reference

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Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319708

Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319708

Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta

15 August 2018

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The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319708

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319708

Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319708

Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319708

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319708

Aging and Innate Immunity

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319708

Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25125468

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3233/JAD-141335

1 reference

14 November 2017

1 reference

14 November 2017

PubMed publication ID

25125468

1 reference