HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity (Q43180179)

15 November 2017

HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity (English)

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15 November 2017

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2

Veronica J Vieland

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15 November 2017

Susan E Hodge

1

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PMCID

384930

15 November 2017

David A Greenberg

series ordinal

3

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PMCID

384930

15 November 2017

language of work or name

English

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publication date

1 February 2002

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American Journal of Human Genetics

15 November 2017

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15 November 2017

70

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15 November 2017

556-559

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15 November 2017

2

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Comparison of 'model-free' and 'model-based' linkage statistics in the presence of locus heterogeneity: single data set and multiple data set applications

15 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: comparative evaluation of model-based linkage methods for affected sib pair data.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Problems in the definition, interpretation, and evaluation of genetic heterogeneity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Further evidence for the increased power of LOD scores compared with nonparametric methods

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Parametric and nonparametric linkage analysis: a unified multipoint approach

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Asymptotic properties of affected-sib-pair linkage analysis.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Two-locus models of disease: comparison of likelihood and nonparametric linkage methods

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Determining trait locus position from multipoint analysis: accuracy and power of three different statistics.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

The null distribution of the heterogeneity lod score does depend on the assumed genetic model for the trait.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Distribution of the admixture test for the detection of linkage under heterogeneity.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=384930

Detection of linkage under heterogeneity: Comparison of the two-locus vs. admixture models

15 August 2018

1 reference

12 December 2020

Quantification of type I error probabilities for heterogeneity LOD scores

1 reference

12 December 2020

HLODs, Trait Models, and Ascertainment: Implications of Admixture for Parameter Estimation and Linkage Detection

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12 December 2020

Linkage analysis and family classification under heterogeneity

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12 December 2020

Effect of heterogeneity and assumed mode of inheritance on lod scores

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12 December 2020

Identifiers

DOI

10.1086/338923

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15 November 2017

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15 November 2017

1 reference

PMCID

384930