Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg? (Q43195722)

15 November 2017

Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg? (English)

1 reference

15 November 2017

Christian P Strassburg

series ordinal

1

1 reference

PubMed ID

20070246

15 November 2017

language of work or name

English

0 references

publication date

1 February 2010

1 reference

15 November 2017

Drug Metabolism Reviews

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15 November 2017

42

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15 November 2017

1

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15 November 2017

168-181

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Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer

15 November 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

A new type of defect in the gene for bilirubin uridine 5'-diphosphate-glucuronosyltransferase in a patient with Crigler-Najjar syndrome type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Alteration of drug metabolism in Gilbert's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Rapid allelic discrimination by TaqMan PCR for the detection of the Gilbert's syndrome marker UGT1A1*28.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Correlation between the UDP-glucuronosyltransferase (UGT1A1) TATAA box polymorphism and carcinogen detoxification phenotype: significantly decreased glucuronidating activity against benzo(a)pyrene-7,8-dihydrodiol(-) in liver microsomes from subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Gilbert's syndrome: High frequency of the (TA)7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

The role of new agents in the treatment of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

UGT1A1 variation and gallstone formation in sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Genome-wide association meta-analysis for total serum bilirubin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Bilirubin: an endogenous product of heme degradation with both cytotoxic and cytoprotective properties

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Effects of Japanese herbal medicine, Kampo, on human UGT1A1 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Frequent co-occurrence of the TATA box mutation associated with Gilbert’s syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Genetic heterogeneity of Crigler-Najjar syndrome type I: a study of 14 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Gilbert??s Syndrome and Drug Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Comparative genomics analysis of human sequence variation in the UGT1A gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? An evidence-based review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Pharmacogenetic study in Hodgkin lymphomas reveals the impact of UGT1A1 polymorphisms on patient prognosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Bilirubin and the risk of common non-hepatic diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Pharmacogenetics of Gilbert's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

Mechanism of indinavir-induced hyperbilirubinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209429

10.3109/03602530903209429

21 January 2018

Identifiers

DOI

1 reference

15 November 2017

1 reference

PubMed ID

20070246