Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies (Q43216496)

16 November 2017

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies (English)

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16 November 2017

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GeneDB

5 February 2019

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GeneDB

6 February 2019

farnesyl pyrophosphate synthase, putative

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6

Eric Oldfield

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16 November 2017

Andrea Montalvetti

1

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16 November 2017

Alexis Fernandez

2

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16 November 2017

John M Sanders

3

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16 November 2017

Subhash Ghosh

4

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16 November 2017

Erin Van Brussel

5

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16 November 2017

Roberto Docampo

7

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16 November 2017

language of work or name

English

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publication date

4 March 2003

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Journal of Biological Chemistry

16 November 2017

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16 November 2017

278

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16 November 2017

19

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16 November 2017

17075-17083

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Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

16 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Activity of bisphosphonates against Trypanosoma brucei rhodesiense

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Overview of bisphosphonates

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Developments in the therapeutic applications of bisphosphonates

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Therapeutic approaches to bone diseases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Cloning and functional expression of a gene encoding a vacuolar-type proton-translocating pyrophosphatase from Trypanosoma cruzi.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Regulation of product chain length by isoprenyl diphosphate synthases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

RASMOL: biomolecular graphics for all

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Molecular analysis of prenyl chain elongating enzymes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

The graphical determination of Km and Ki

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Purification and characterization of recombinant human farnesyl diphosphate synthase expressed in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Structure-activity relationships of various bisphosphonates

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

The fall and rise of sleeping sickness

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Mechanisms of action of bisphosphonates

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210467200

Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Inhibition of bloodstream form Trypanosoma brucei gene expression by RNA interference using the pZJM dual T7 vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Studies on novel bone resorption inhibitors. II. Synthesis and pharmacological activities of fused aza-heteroarylbisphosphonate derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Analog inhibitors for the pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica and their effect on culture growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

21 January 2018

Identifiers

DOI

10.1074/JBC.M210467200

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release_y7fucf4qhfhdnoxwydzbvpghtu

16 November 2017

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Fatcat

https://api.fatcat.wiki/v0/release/y7fucf4qhfhdnoxwydzbvpghtu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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