Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth (Q43270642)

17 November 2017

Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth (English)

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17 November 2017

retinal ganglion cell

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7

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17 November 2017

Michael R Douglas

1

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17 November 2017

Kevin C Morrison

2

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17 November 2017

Steven J Jacques

3

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17 November 2017

Wendy E Leadbeater

4

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17 November 2017

Ana Maria Gonzalez

5

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17 November 2017

Martin Berry

6

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17 November 2017

Zubair Ahmed

8

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17 November 2017

language of work or name

English

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publication date

25 September 2009

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17 November 2017

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17 November 2017

132

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17 November 2017

Pt 11

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17 November 2017

3102-3121

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ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors.

17 November 2017

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

p75NTR is positively promiscuous: novel partners and new insights

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Optic nerve regeneration after intravitreal peripheral nerve implants: trajectories of axons regrowing through the optic chiasm into the optic tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Cytology and lineage of NG2-positive glia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Characterization of Nerve Growth Factor (NGF) Release from Hippocampal Neurons: Evidence for a Constitutive and an Unconventional Sodium‐dependent Regulated Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Synantocytes: new functions for novel NG2 expressing glia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Neurotrophin release by neurotrophins: implications for activity-dependent neuronal plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Neurons and astrocytes secrete factors that cause stem cells to differentiate into neurons and astrocytes, respectively.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Neurotrophin signalling in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Epidermal growth factor receptor in adult retinal neurons of rat, mouse, and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Müller glia factors induce survival and neuritogenesis of peripheral and central neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Pro-NGF secreted by astrocytes promotes motor neuron cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Reactive astrogliosis induces astrocytic differentiation of adult neural stem/progenitor cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Combined therapies in the treatment of neurotrauma: polymers, bridges and gene therapy in visual system repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Gene therapy and transplantation in CNS repair: the visual system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Lentiviral-mediated transfer of CNTF to schwann cells within reconstructed peripheral nerve grafts enhances adult retinal ganglion cell survival and axonal regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Trk receptors: roles in neuronal signal transduction

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Signal transduction by the neurotrophin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Neurotrophins induce release of neurotrophins by the regulated secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Cooperative effects of bcl-2 and AAV-mediated expression of CNTF on retinal ganglion cell survival and axonal regeneration in adult transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Changes in epidermal growth factor receptor expression and competence to generate glia regulate timing and choice of differentiation in the retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Activation of epidermal growth factor receptor signals induction of nitric oxide synthase-2 in human optic nerve head astrocytes in glaucomatous optic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Activation of epidermal growth factor receptors directs astrocytes to organize in a network surrounding axons in the developing rat optic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Activation of epidermal growth factor receptors in astrocytes: from development to neural injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Different factors promote axonal regeneration of adult rat retinal ganglion cells after lens injury and intravitreal peripheral nerve grafting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Effect of lens lesion on neurite outgrowth of retinal ganglion cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

K252a inhibits the oncogenic properties of Met, the HGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Cytokine-induced SOCS expression is inhibited by cAMP analogue: impact on regeneration in injured retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Epidermal growth factor receptor in proliferating reactive glia following transient focal ischemia in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

cAMP regulates axon outgrowth and guidance during optic nerve regeneration in goldfish

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Neurotrophin signaling through the p75 neurotrophin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Ciliary neurotrophic factor and its receptors are differentially expressed in the optic nerve transected adult rat retina.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Müller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Müller cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Optimisation of siRNA-mediated RhoA silencing in neuronal cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

Differential regulation of neurotrophin expression in basal forebrain astrocytes by neuronal signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWP240

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWP240

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17 November 2017

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