Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model (Q43298538)

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scientific article published on 5 August 2009

Language	Label	Description	Also known as
English	Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model	scientific article published on 5 August 2009

Statements

scholarly article

1 reference

Europe PubMed Central

18 November 2017

Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model (English)

1 reference

Europe PubMed Central

18 November 2017

author name string

Nobuyuki Tai

1

1 reference

Europe PubMed Central

18 November 2017

K Kuwabara

2

1 reference

Europe PubMed Central

18 November 2017

M Kobayashi

3

1 reference

Europe PubMed Central

18 November 2017

K Yamada

4

1 reference

Europe PubMed Central

18 November 2017

T Ono

5

1 reference

Europe PubMed Central

18 November 2017

K Seno

6

1 reference

Europe PubMed Central

18 November 2017

Y Gahara

7

1 reference

Europe PubMed Central

18 November 2017

J Ishizaki

8

1 reference

Europe PubMed Central

18 November 2017

Y Hori

9

1 reference

Europe PubMed Central

18 November 2017

publication date

5 August 2009

1 reference

Europe PubMed Central

18 November 2017

Inflammation Research

1 reference

Europe PubMed Central

18 November 2017

59

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Europe PubMed Central

18 November 2017

1

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Europe PubMed Central

18 November 2017

53-62

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Europe PubMed Central

18 November 2017

https://scigraph.springernature.com/pub.10.1007/s00011-009-0069-8

0 references

Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s.

1 reference

https://api.crossref.org/works/10.1007%2FS00011-009-0069-8

21 January 2018

Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts

1 reference

https://api.crossref.org/works/10.1007%2FS00011-009-0069-8

21 January 2018

Increasing molecular diversity of secreted phospholipases A(2) and their receptors and binding proteins

1 reference

https://api.crossref.org/works/10.1007%2FS00011-009-0069-8

21 January 2018

Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 1 mediated acceleration of type II collagen-induced arthritis: effects of anti-inflammatory or anti-arthritic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 amplifies cytosolic phospholipase A2- and cyclooxygenase-2-dependent delayed prostaglandin E2 generation in mouse osteoblastic cells. Enhancement by secretory phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase A2 activation in human neutrophils requires influx of extracellular Ca2+ and leukotriene B4

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukotriene B4 stimulates the release of arachidonate in human neutrophils via the action of cytosolic phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoimmunity to type II collagen an experimental model of arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of group IIA phospholipase A2 in rat colitis induced by dextran sulfate sodium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of murine endotoxic shock by sPLA2 inhibitor, indoxam, through group IIA sPLA2-independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Role of matrix metalloproteinase-3 in joint destruction in rheumatoid arthritis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytosolic Phospholipase A2α–deficient Mice Are Resistant to Collagen-induced Arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superantigen-induced collagenase gene expression in human IFN-gamma-treated fibroblast-like synoviocytes involves prostaglandin E2. Evidence for a role of cyclooxygenase-2 and cytosolic phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the second-generation leukotriene B(4) receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunisation against heterologous type II collagen induces arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of cytokine synthesis, integrin expression and chronic inflammation by inhibitors of cytosolic phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of the Group IV phospholipase A2 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: correlation with lung surfactant protection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of secretory group IIa and V phospholipase A2 and cytosolic group IValpha phospholipase A2 in chondrocytes from patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2–mediated Bone Resorption Associated with Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetic ablation of cyclooxygenase 2 prevents the development of autoimmune arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytosolic phospholipase A2 in allergic response and parturition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyrrolidine inhibitors of human cytosolic phospholipase A(2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, double-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of synovial fluid lipoproteins to the chronic synovitis of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide induction of monocyte matrix metalloproteinases is regulated by the tyrosine phosphorylation of cytosolic phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cPLA2 is phosphorylated and activated by MAP kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00011-009-0069-8

1 reference

Europe PubMed Central

18 November 2017

1 reference

Europe PubMed Central

18 November 2017

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