The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase (Q43510103)

24 November 2017

The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase (English)

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24 November 2017

2

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24 November 2017

M L Steinhilb

1

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PubMed ID

11084038

24 November 2017

J R Gaut

series ordinal

3

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PubMed ID

11084038

24 November 2017

language of work or name

English

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publication date

17 November 2000

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Journal of Biological Chemistry

24 November 2017

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24 November 2017

276

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24 November 2017

4476-4484

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24 November 2017

6

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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

24 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M008793200

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Expression analysis of BACE2 in brain and peripheral tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Calpain inhibitor I decreases beta A4 secretion from human embryonal kidney cells expressing beta-amyloid precursor protein carrying the APP670/671 double mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Effects of specific protease inhibitors on amyloid beta-protein 42 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Proteasome inhibitors: valuable new tools for cell biologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008793200

21 January 2018

Identifiers

DOI

10.1074/JBC.M008793200

1 reference

24 November 2017

1 reference

PubMed ID

11084038