Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy. (Q43521257)

PubMed publication ID

23966299

24 November 2017

title

Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6324537&resulttype=core&format=json

13 May 2020

7

Stuart H Yuspa

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13 May 2020

author name string

Francesca Mascia

1

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13 May 2020

Gary Lam

2

1 reference

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13 May 2020

Christopher Keith

3

1 reference

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13 May 2020

Caroline Garber

4

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13 May 2020

Seth M Steinberg

5

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13 May 2020

Elise Kohn

6

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13 May 2020

language of work or name

English

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publication date

1 August 2013

1 reference

PubMed publication ID

23966299

Science Translational Medicine

24 November 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6324537&resulttype=core&format=json

13 May 2020

volume

5

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13 May 2020

issue

199

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13 May 2020

page(s)

199ra110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6324537&resulttype=core&format=json

EGFR antagonists in cancer treatment

13 May 2020

cites work

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Mechanisms of cutaneous toxicities to EGFR inhibitors.

21 January 2018

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Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy.

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Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?

21 January 2018

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Characterisation of the cutaneous pathology in non-small cell lung cancer (NSCLC) patients treated with the EGFR tyrosine kinase inhibitor erlotinib

21 January 2018

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Investigation of papulopustular eruptions caused by cetuximab treatment shows altered differentiation markers and increases in inflammatory cytokines

21 January 2018

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Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart

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Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation

21 January 2018

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Inflammatory skin and bowel disease linked to ADAM17 deletion

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Serum biomarkers as potential predictors of antitumor activity of cetuximab-containing therapy for locally advanced head and neck cancer

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Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer

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Plasma MIP-1beta levels and skin toxicity in Japanese non-small cell lung cancer patients treated with the EGFR-targeted tyrosine kinase inhibitor, gefitinib

21 January 2018

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A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer

21 January 2018

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A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination

21 January 2018

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Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor

21 January 2018

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Epidermal barrier formation and recovery in skin disorders

21 January 2018

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Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

21 January 2018

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

21 January 2018

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Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death

21 January 2018

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Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.

21 January 2018

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A critical role for macrophages in promotion of urethane-induced lung carcinogenesis

21 January 2018

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Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

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The black box illuminated: signals and signaling

21 January 2018

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Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice.

21 January 2018

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Epidermal EGFR controls cutaneous host defense and prevents inflammation

21 January 2018

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Preliminary evidence for a role of mast cells in epidermal growth factor receptor inhibitor-induced pruritus.

21 January 2018

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Direct and indirect anticancer activity of bisphosphonates: a brief review of published literature

21 January 2018

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Tetracyclines convert the osteoclastic-differentiation pathway of progenitor cells to produce dendritic cell-like cells.

21 January 2018

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Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities.

21 January 2018

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Epidermal growth factor receptor inhibits colitis-associated cancer in mice

21 January 2018

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Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism

21 January 2018

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Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

21 January 2018

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Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo

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12 December 2020

ERK1/2 regulates epidermal chemokine expression and skin inflammation

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12 December 2020

Elevation of soluble interleukin-2 receptor in patients with non-small cell lung cancer treated with gefitinib

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12 December 2020

Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies

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12 December 2020

Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

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12 December 2020

Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure

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12 December 2020

Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development

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12 December 2020

10.1126/SCITRANSLMED.3005773

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6324537&resulttype=core&format=json

release_zqrzbqcl7rabvi3hfcouthbzeu

13 May 2020

Fatcat ID

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Fatcat

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24 November 2022

mapped directly with Wikidata item

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13 May 2020

PubMed publication ID

23966299

1 reference