A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal (Q43543397)

24 November 2017

A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal (English)

1 reference

24 November 2017

7

1 reference

24 November 2017

3

Veronika Jesenberger

1 reference

24 November 2017

Gergana Galabova-Kovacs

4

object named as

Gergana Galabova-Kovacs

1 reference

24 November 2017

Federica Catalanotti

1

1 reference

24 November 2017

Gloria Reyes

2

1 reference

24 November 2017

Ricardo de Matos Simoes

5

1 reference

24 November 2017

Oliviero Carugo

6

1 reference

24 November 2017

language of work or name

1 reference

15 February 2009

1 reference

Nature Structural & Molecular Biology

24 November 2017

1 reference

24 November 2017

16

1 reference

24 November 2017

3

1 reference

24 November 2017

294-303

1 reference

https://scigraph.springernature.com/pub.10.1038/nsmb.1564

24 November 2017

0 references

cites work

Ras nanoclusters: combining digital and analog signaling

1 reference

Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation

21 January 2018

1 reference

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

21 January 2018

1 reference

Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway

31 March 2020

1 reference

Mutations of the BRAF gene in human cancer

31 March 2020

1 reference

Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy

31 March 2020

1 reference

MAP kinases and cell migration

31 March 2020

1 reference

A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase.

31 March 2020

1 reference

Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

31 March 2020

1 reference

The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo

31 March 2020

1 reference

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

31 March 2020

1 reference

IQGAP1 is a scaffold for mitogen-activated protein kinase signaling

31 March 2020

1 reference

GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor

31 March 2020

1 reference

Mek2 is dispensable for mouse growth and development

31 March 2020

1 reference

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

31 March 2020

1 reference

Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis.

31 March 2020

1 reference

Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.

31 March 2020

1 reference

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

31 March 2020

1 reference

Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion

31 March 2020

1 reference

Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain

31 March 2020

1 reference

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

31 March 2020

1 reference

Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development

31 March 2020

1 reference

MEK1 and MEK2, different regulators of the G1/S transition.

31 March 2020

1 reference

Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

31 March 2020

1 reference

MEK1 activation by PAK: a novel mechanism

31 March 2020

1 reference

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

31 March 2020

1 reference

Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation

31 March 2020

1 reference

Regulation of Raf-1 by direct feedback phosphorylation.

31 March 2020

1 reference

Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

31 March 2020

1 reference

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

31 March 2020

1 reference

Regulation and role of Raf-1/B-Raf heterodimerization

31 March 2020

1 reference

The RAF proteins take centre stage

31 March 2020

1 reference

Integrin signalling in directed cell migration.

31 March 2020

1 reference

Blastocysts don't go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells

31 March 2020

1 reference

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

31 March 2020

1 reference

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

31 March 2020

1 reference

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

31 March 2020

1 reference

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

31 March 2020

1 reference

Raf-1 regulates Rho signaling and cell migration

31 March 2020

1 reference

M-Coffee: combining multiple sequence alignment methods with T-Coffee

31 March 2020

1 reference

ProbCons: Probabilistic consistency-based multiple sequence alignment

31 March 2020

1 reference

MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform

31 March 2020

1 reference

MUSCLE: multiple sequence alignment with high accuracy and high throughput

31 March 2020

1 reference

IQPNNI: moving fast through tree space and stopping in time.

31 March 2020

1 reference

BRAF and MEK mutations make a late entrance

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19219045

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19219045

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Active Ras induces heterodimerization of cRaf and BRaf

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19219045

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1564

1 reference

24 November 2017

1 reference