Identification of multiple sources of charge heterogeneity in a recombinant antibody. (Q43555101)

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5 November 2019

title

Identification of multiple sources of charge heterogeneity in a recombinant antibody (English)

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5 November 2019

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R J Harris

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5 November 2019

B Kabakoff

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5 November 2019

F D Macchi

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5 November 2019

F J Shen

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5 November 2019

M Kwong

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5 November 2019

J D Andya

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5 November 2019

S J Shire

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5 November 2019

N Bjork

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K Totpal

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5 November 2019

A B Chen

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5 November 2019

publication date

1 March 2001

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Journal of Chromatography B: Biomedical Sciences and Applications

5 November 2019

published in

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5 November 2019

volume

752

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5 November 2019

issue

2

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5 November 2019

page(s)

233-245

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The covalent structure of an entire gammaG immunoglobulin molecule

5 November 2019

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Comparative structural study of the N-linked oligosaccharides of human normal and pathological immunoglobulin G

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Identification of sites of degradation in a therapeutic monoclonal antibody by peptide mapping

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Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions

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7 January 2021

Monitoring of IgG antibody thermal stability by micellar electrokinetic capillary chromatography and matrix-assisted laser desorption/ionization mass spectrometry.

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7 January 2021

Origin of the isoelectric heterogeneity of monoclonal immunoglobulin h1B4.

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A high-throughput microscale method to release N-linked oligosaccharides from glycoproteins for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis

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7 January 2021

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7 January 2021

Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture.

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Rapid analytical tryptic mapping of a recombinant chimeric monoclonal antibody and method validation challenges

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Characterization of humanized anti-TAC, an antibody directed against the interleukin 2 receptor, using electrospray ionization mass spectrometry by direct infusion, LC/MS, and MS/MS.

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7 January 2021

An integrated strategy for structural characterization of the protein and carbohydrate components of monoclonal antibodies: application to anti-respiratory syncytial virus MAb.

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7 January 2021

Identification of succinimide sites in proteins by N-terminal sequence analysis after alkaline hydroxylamine cleavage

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7 January 2021

Isomerization of an aspartic acid residue in the complementarity-determining regions of a recombinant antibody to human IgE: identification and effect on binding affinity.

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7 January 2021

Validation of an HPLC method for the analysis of the charge heterogeneity of the recombinant monoclonal antibody IDEC-C2B8 after papain digestion

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7 January 2021

Herceptin: breaking new ground

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7 January 2021

Humanization of an anti-p185HER2 antibody for human cancer therapy

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7 January 2021

Chemical pathways of peptide degradation. IV. Pathways, kinetics, and mechanism of degradation of an aspartyl residue in a model hexapeptide

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7 January 2021

Sequence-specific deamidation: isolation and biochemical characterization of succinimide intermediates of recombinant hirudin.

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7 January 2021

Tertiary Structure Is a Principal Determinant to Protein Deamidation

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7 January 2021

Isolation and characterization of porcine somatotropin containing a succinimide residue in place of aspartate129

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7 January 2021

Major degradation products of basic fibroblast growth factor: detection of succinimide and iso-aspartate in place of aspartate

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7 January 2021

Isolation and characterization of 101-succinimide lysozyme that possesses the cyclic imide at Asp101-Gly102

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7 January 2021

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments

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7 January 2021

X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling

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7 January 2021

Sequence and structure determinants of the nonenzymatic deamidation of asparagine and glutamine residues in proteins

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7 January 2021

10.1016/S0378-4347(00)00548-X

Identifiers

DOI

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5 November 2019

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