LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine (Q43579801)

24 November 2017

LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine (English)

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24 November 2017

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Marie Isabelle Garcia

1

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24 November 2017

Mariangela Ghiani

2

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24 November 2017

Anne Lefort

3

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24 November 2017

Frédérick Libert

4

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24 November 2017

Sandra Strollo

5

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24 November 2017

Gilbert Vassart

6

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24 November 2017

language of work or name

English

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publication date

24 April 2009

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24 November 2017

10

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based on heuristic

inferred from page(s)

published in

Developmental Biology

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24 November 2017

331

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24 November 2017

1

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24 November 2017

58-67

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Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine.

24 November 2017

1 reference

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A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation.

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Identification of stem cells in small intestine and colon by marker gene Lgr5

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Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

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Paneth cell differentiation in the developing intestine of normal and transgenic mice

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A novel modulatory mechanism of transforming growth factor-beta signaling through decorin and LRP-1.

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell.

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Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine

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Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

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Notch signals control the fate of immature progenitor cells in the intestine

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NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells

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Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea

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Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region

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Postnatal changes in the expression of genes for cryptdins 1-6 and the role of luminal bacteria in cryptdin gene expression in mouse small intestine.

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

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Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia

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The Hes gene family: repressors and oscillators that orchestrate embryogenesis

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A critical role for elastin signaling in vascular morphogenesis and disease

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Phases of canonical Wnt signaling during the development of mouse intestinal epithelium

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1 reference

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

7 January 2021

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Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

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The intestinal epithelial stem cell

7 January 2021

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Defective postnatal development of the male reproductive tract in LGR4 knockout mice

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Cell-specific expression of alpha 1-antitrypsin in human intestinal epithelium

7 January 2021

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Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension

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Capturing and profiling adult hair follicle stem cells.

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Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling.

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Wnt, stem cells and cancer in the intestine

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Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

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The "normal" endocrine cell of the gut: changing concepts and new evidences

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The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway

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Bmi1 is expressed in vivo in intestinal stem cells

7 January 2021

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

7 January 2021

1 reference

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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Current view: intestinal stem cells and signaling

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Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40

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Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine

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Dietary zinc deficiency and repletion modulate metallothionein immunolocalization and concentration in small intestine and liver of rats

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Significance analysis of microarrays applied to the ionizing radiation response

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Transcription factor achaete scute-like 2 controls intestinal stem cell fate

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1 reference

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Wnt signalling induces maturation of Paneth cells in intestinal crypts

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1 reference

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Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity

7 January 2021

1 reference

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Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling

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Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors

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Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal Tumorigenesis

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10.1016/J.YDBIO.2009.04.020

7 January 2021

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DOI

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24 November 2017

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