Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. (Q43597583)

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4 January 2020

title

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent (English)

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4 January 2020

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6

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4 January 2020

Rachel F Tyndale

7

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4 January 2020

author name string

Jill C Mwenifumbo

1

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4 January 2020

Nael Al Koudsi

2

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4 January 2020

Man Ki Ho

3

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4 January 2020

Qian Zhou

4

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4 January 2020

Ewa B Hoffmann

5

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publication date

1 May 2008

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4 January 2020

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4 January 2020

volume

29

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issue

5

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4 January 2020

page(s)

679-688

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Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics

4 January 2020

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Female sex and oral contraceptive use accelerate nicotine metabolism

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Expression and alternative splicing of the cytochrome P-450 CYP2A7

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Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers

21 January 2018

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A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo

21 January 2018

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A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity.

21 January 2018

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Genotyping human CYP2A6 variants

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Three haplotypes associated with CYP2A6 phenotypes in Caucasians

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Ethnic and racial differences in the smoking-related risk of lung cancer

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Useful 'junk': Alu RNAs in the human transcriptome

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A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent

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Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19.

21 January 2018

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Whole deletion of CYP2A6 gene (CYP2A6AST;4C) and smoking behavior

21 January 2018

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CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity

21 January 2018

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Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes

21 January 2018

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Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy

21 January 2018

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Limitation of cigarette consumption by CYP2A6*4, *7 and *9 polymorphisms

21 January 2018

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Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method.

21 January 2018

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Genetic variability in CYP2A6 and the pharmacokinetics of nicotine

21 January 2018

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Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking.

21 January 2018

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Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism.

21 January 2018

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Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

21 January 2018

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Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity

21 January 2018

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A nicotine C-oxidase gene (CYP2A6) polymorphism important for promoter activity

21 January 2018

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A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

21 January 2018

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Catalog of 680 variations among eight cytochrome P450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population

21 January 2018

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Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects

21 January 2018

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Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration

21 January 2018

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Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5.

21 January 2018

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Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population

21 January 2018

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21 January 2018

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Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver

21 January 2018

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Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted

21 January 2018

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Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

21 January 2018

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Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism

21 January 2018

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A novel duplication type of CYP2A6 gene in African-American population

21 January 2018

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7 January 2021

The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit

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7 January 2021

Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers

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7 January 2021

Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population

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7 January 2021

Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking

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7 January 2021

Identifiers

DOI

10.1002/HUMU.20698

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18360915%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference