Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells (Q43630502)

25 November 2017

title

Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells (English)

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25 November 2017

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5

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25 November 2017

McNeish IA

1

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25 November 2017

Tenev T

2

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25 November 2017

Bell S

3

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25 November 2017

Marani M

4

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25 November 2017

Lemoine N

6

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25 November 2017

publication date

1 April 2001

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25 November 2017

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25 November 2017

volume

8

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25 November 2017

issue

4

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25 November 2017

page(s)

308-319

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Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

25 November 2017

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Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.

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New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol

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Successful use of a plant gene in the treatment of cancer in vivo

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In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors

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A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group

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In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial.

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The equine herpes virus 4 thymidine kinase is a better suicide gene than the human herpes virus 1 thymidine kinase

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Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant

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Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo

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Combination gene therapy for liver metastasis of colon carcinoma in vivo

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Limited efficacy of the HSV-TK/GCV system for gene therapy of malignant gliomas and perspectives for the combined transduction of the interleukin-4 gene

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Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase

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Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.

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7 January 2021

Caspase structure, proteolytic substrates, and function during apoptotic cell death

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Adenovirus-mediated transfer of caspase-3 with Fas ligand induces drastic apoptosis in U-373MG glioma cells

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Cancer gene therapy using a pro-apoptotic gene, caspase-3.

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Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits

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Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.

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Inhibition of human caspases by peptide-based and macromolecular inhibitors

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Perinuclear localization of the protein-tyrosine phosphatase SHP-1 and inhibition of epidermal growth factor-stimulated STAT1/3 activation in A431 cells

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7 January 2021

Use of transcriptional regulatory elements of the MUC1 and ERBB2 genes to drive tumour-selective expression of a prodrug activating enzyme

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7 January 2021

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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7 January 2021

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

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7 January 2021

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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7 January 2021

A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity

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7 January 2021

Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis

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Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

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7 January 2021

Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells

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Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways

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7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700305

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Dimensions Publication ID

25 November 2017

1050932979

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