Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment (Q43633330)

25 November 2017

title

Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment (English)

1 reference

25 November 2017

1

1 reference

25 November 2017

M W Himmelstein

2

1 reference

25 November 2017

M L Gargas

series ordinal

3

1 reference

25 November 2017

publication date

1 June 2001

1 reference

Chemico-biological Interactions

25 November 2017

published in

1 reference

25 November 2017

volume

135-136

1 reference

25 November 2017

page(s)

303-322

1 reference

Carcinogenicity of inhaled butadiene diepoxide in female B6C3F1 mice and Sprague-Dawley rats

25 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Physiologically based pharmacokinetic modeling of 1,3-butadiene, 1,2- epoxy-3-butene, and 1,2:3,4-diepoxybutane toxicokinetics in mice and rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Review of reproductive and developmental toxicity of 1,3-butadiene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Environmental toxicants and female reproduction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Environment, human reproduction, menopause, and andropause

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Factors associated with early menopause

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Species difference in the ovarian toxicity of 1,3-butadiene epoxides in B6C3F1 mice and Sprague-Dawley rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Development of a physiologically based pharmacokinetic model for chloroform

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Subchronic toxicity of 4-vinylcyclohexene in rats and mice by inhalation exposure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Disposition of butadiene monoepoxide and butadiene diepoxide in various tissues of rats and mice following a low-level inhalation exposure to 1,3-butadiene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Optimal design for a study of butadiene toxicokinetics in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Comparative metabolism of low concentrations of butadiene and its monoepoxide in human and monkey hepatic microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Toxicology and epidemiology of 1,3-butadiene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Physiological Parameter Values for Physiologically Based Pharmacokinetic Models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Biomarkers of exposure to 1,3-butadiene as a basis for cancer risk assessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Time concepts in physics, biology, and pharmacokinetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

A Physiologically Based Pharmacokinetic (PB-PK) Model for 1,2-Dichlorobenzene Linked to Two Possible Parameters of Toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

The Use of Humanin VitroMetabolic Parameters to Explore the Risk Assessment of Hazardous Compounds: The Case of Ethylene Dibromide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Glutathione conjugation of 1,2:3,4- diepoxybutane in human liver and rat and mouse liver and lung in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

The role of hydrolysis in the detoxification of 1,2:3,4-diepoxybutane by human, rat, and mouse liver and lung in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Enzyme specific kinetics of 1,2-epoxybutene-3 in microsomes and cytosol from livers of mouse, rat, and man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Oxidation of 3-butene-1,2-diol by alcohol dehydrogenase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Oxidation of butadiene monoxide to meso- and (+/-)-diepoxybutane by cDNA-expressed human cytochrome P450s and by mouse, rat, and human liver microsomes: evidence for preferential hydration of meso-diepoxybutane in rat and human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Species differences in urinary butadiene metabolites: comparisons of metabolite ratios between mice, rats, and humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Genotoxic markers among butadiene polymer workers in China.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

In vivo pharmacokinetics of felodipine predicted from in vitro studies in rat, dog and man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

A physiological toxicokinetic model for 1,3-butadiene in rodents and man: blood concentrations of 1,3-butadiene, its metabolically formed epoxides, and of haemoglobin adducts--relevance of glutathione depletion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

In vivo metabolism of butadiene by mice and rats: a comparison of physiological model predictions and experimental data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

Species differences in the production and clearance of 1,3-butadiene metabolites: a mechanistic model indicates predominantly physiological, not biochemical, control.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

A physiologically based pharmacokinetic model for butadiene and its metabolite butadiene monoxide in rat and mouse and its significance for risk extrapolation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2801%2900177-6

10.1016/S0009-2797(01)00177-6

7 January 2021

Identifiers

DOI

1 reference

25 November 2017

1 reference