Activation of p53 by roscovitine-mediated suppression of MDM2 expression (Q43652194)

25 November 2017

Activation of p53 by roscovitine-mediated suppression of MDM2 expression (English)

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25 November 2017

W Lu

1

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25 November 2017

L Chen

series ordinal

2

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25 November 2017

Y Peng

series ordinal

3

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25 November 2017

J Chen

series ordinal

4

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25 November 2017

language of work or name

English

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publication date

1 May 2001

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25 November 2017

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25 November 2017

20

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25 November 2017

25

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25 November 2017

3206-3216

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204412

25 November 2017

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cites work

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Mapping of the p53 and mdm-2 interaction domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Mutation of phosphoserine 389 affects p53 function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Distinct roles for cyclin-dependent kinases in cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Activation of p53 in cervical carcinoma cells by small molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Nuclear exclusion of p53 in a subset of tumors requires MDM2 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Altered expression of the p53-regulated proteins, p21Waf1/Cip1, MDM2, and Bax in ultraviolet-irradiated human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Inhibition of cyclin-dependent kinases by purine analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

Transcription abnormalities potentiate apoptosis of normal human fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

7 January 2021

Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

7 January 2021

Inhibition of RNA polymerase II as a trigger for the p53 response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

7 January 2021

Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

7 January 2021

Transcription of herpes simplex virus immediate-early and early genes is inhibited by roscovitine, an inhibitor specific for cellular cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

7 January 2021

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

7 January 2021

Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204412

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204412

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Dimensions Publication ID

25 November 2017

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