The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity. (Q43698671)

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10 November 2019

title

The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity (English)

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10 November 2019

6

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10 November 2019

author name string

D Bom

1

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10 November 2019

D P Curran

2

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10 November 2019

J Zhang

3

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10 November 2019

S G Zimmer

4

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10 November 2019

R Bevins

5

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10 November 2019

J N Howe

7

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10 November 2019

A Bingcang

8

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10 November 2019

L J Latus

9

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10 November 2019

T G Burke

10

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10 November 2019

language of work or name

English

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publication date

1 July 2001

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Journal of Controlled Release

10 November 2019

published in

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10 November 2019

volume

74

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10 November 2019

issue

1-3

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10 November 2019

page(s)

325-333

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Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

10 November 2019

cites work

1 reference

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Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogues. Structure-activity correlations

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7 January 2021

Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin

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7 January 2021

DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts

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7 January 2021

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

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7 January 2021

Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors

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7 January 2021

The current status of camptothecin analogues as antitumor agents

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7 January 2021

Lipid bilayer partitioning and stability of camptothecin drugs

1 reference

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7 January 2021

Preferential binding of the carboxylate form of camptothecin by human serum albumin

1 reference

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7 January 2021

Differential interactions of camptothecin lactone and carboxylate forms with human blood components.

1 reference

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7 January 2021

The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity

1 reference

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7 January 2021

10.1016/S0168-3659(01)00343-1

Identifiers

DOI

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10 November 2019

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