Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210. (Q43733743)

26 November 2017

Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210. (English)

1 reference

26 November 2017

Plasmodium falciparum

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pyrimethamine

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author name string

Hankins EG

series ordinal

1

1 reference

PubMed ID

11551635

26 November 2017

Warhurst DC

series ordinal

2

1 reference

PubMed ID

11551635

26 November 2017

Sibley CH

series ordinal

3

1 reference

26 November 2017

1 September 2001

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Molecular and Biochemical Parasitology

26 November 2017

1 reference

26 November 2017

117

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26 November 2017

1

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26 November 2017

91-102

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Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria

26 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Molecular epidemiology of malaria in Yaounde, Cameroon I. Analysis of point mutations in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

1 reference

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7 January 2021

Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Pyrimethamine resistant mutations in Plasmodium falciparum

1 reference

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7 January 2021

Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea

1 reference

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7 January 2021

Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins

1 reference

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7 January 2021

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

1 reference

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7 January 2021

Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance

1 reference

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7 January 2021

Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa.

1 reference

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7 January 2021

Transmission intensity and Plasmodium falciparum diversity on the northwestern border of Thailand

1 reference

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7 January 2021

Molecular assays for surveillance of antifolate-resistant malaria

1 reference

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7 January 2021

High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance.

1 reference

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7 January 2021

The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites

1 reference

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7 January 2021

Use of a semi-nested PCR diagnosis test to evaluate antifolate resistance of Plasmodium falciparum isolates

1 reference

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7 January 2021

Association between antifol resistance in vitro and DHFR gene point mutation in Plasmodium falciparum isolates

1 reference

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7 January 2021

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum

1 reference

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7 January 2021

Antimalarial drug resistance: the pace quickens

1 reference

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7 January 2021

Epidemiology of drug resistance in malaria

1 reference

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7 January 2021

Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range

1 reference

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7 January 2021

The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses

1 reference

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7 January 2021

Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand

1 reference

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7 January 2021

In vitro activities of and mechanisms of resistance to antifol antimalarial drugs

1 reference

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7 January 2021

Plasmodium falciparum: direct cloning and expression of pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase domains

1 reference

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7 January 2021

PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.

1 reference

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7 January 2021

Activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum in an in vivo-in vitro model.

1 reference

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7 January 2021

Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Randomization of genes by PCR mutagenesis

1 reference

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7 January 2021

Hypermutagenic PCR involving all four transitions and a sizeable proportion of transversions.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Random mutagenesis of gene-sized DNA molecules by use of PCR with Taq DNA polymerase

1 reference

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7 January 2021

Yeast as a model system to study drugs effective against apicomplexan proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Nucleotide sequence of the dihydrofolate reductase gene of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast

1 reference

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7 January 2021

Identification and analysis of dihydrofolate reductase alleles from Plasmodium falciparum present at low frequency in polyclonal patient samples.

1 reference

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7 January 2021

Efficacies of lipophilic inhibitors of dihydrofolate reductase against parasitic protozoa

1 reference

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7 January 2021

Mutagenesis of dihydrofolate reductase from Plasmodium falciparum: analysis in Saccharomyces cerevisiae of triple mutant alleles resistant to pyrimethamine or WR99210.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Population genetics and dynamics of Plasmodium falciparum: an ecological view

1 reference

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7 January 2021

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria

1 reference

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2801%2900335-8

7 January 2021

10.1016/S0166-6851(01)00335-8

Identifiers

DOI

1 reference

26 November 2017

1 reference

PubMed ID

11551635