Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells (Q43734888)

26 November 2017

title

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells (English)

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26 November 2017

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Daniela Bossi

6

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Chiara Ronchini

object named as

Chiara Ronchini

7

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Myriam Alcalay

object named as

Myriam Alcalay

12

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Saverio Minucci

13

object named as

Saverio Minucci

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26 November 2017

Andrea Viale

1

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26 November 2017

Francesca De Franco

2

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26 November 2017

Annette Orleth

3

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26 November 2017

Valeria Cambiaghi

4

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26 November 2017

Virginia Giuliani

5

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26 November 2017

Simona Ronzoni

8

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26 November 2017

Ivan Muradore

9

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26 November 2017

Silvia Monestiroli

10

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26 November 2017

Alberto Gobbi

11

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26 November 2017

Pier Giuseppe Pelicci

14

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26 November 2017

language of work or name

English

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publication date

1 January 2009

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26 November 2017

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26 November 2017

volume

457

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26 November 2017

issue

7225

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26 November 2017

page(s)

51-56

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Long-term erythropoietic repopulating ability of old, young, and fetal stem cells

26 November 2017

cites work

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https://api.crossref.org/works/10.1038%2FNATURE07618

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure

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Hematopoietic stem-cell behavior in nonhuman primates

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Cell cycle inhibitors in normal and tumor stem cells

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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https://api.crossref.org/works/10.1038%2FNATURE07618

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

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Concepts of human leukemic development.

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PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

21 January 2018

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High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression

21 January 2018

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Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

21 January 2018

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Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

21 January 2018

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Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy

21 January 2018

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Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

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Cell intrinsic alterations underlie hematopoietic stem cell aging.

21 January 2018

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Age-associated characteristics of murine hematopoietic stem cells

21 January 2018

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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

21 January 2018

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DNA repair is limiting for haematopoietic stem cells during ageing

21 January 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

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The DNA damage response during DNA replication

21 January 2018

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p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

21 January 2018

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DNA damage-dependent cell cycle checkpoints and genomic stability

21 January 2018

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Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

21 January 2018

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Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

21 January 2018

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

21 January 2018

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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Transgenic expression of E2F3a causes DNA damage leading to ATM-dependent apoptosis.

21 January 2018

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DNA damage signalling guards against activated oncogenes and tumour progression

21 January 2018

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Cellular senescence: when bad things happen to good cells

21 January 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

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Core-binding factors in haematopoiesis and leukaemia

21 January 2018

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Repair of ethylnitrosourea-induced DNA damage in the newborn rat. I. Alkali-labile lesions and in situ breaks.

21 January 2018

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DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors

21 January 2018

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Suffering in silence: the tolerance of DNA damage

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DNA damage control by novel DNA polymerases: translesion replication and mutagenesis

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Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML).

21 January 2018

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.

21 January 2018

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Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

21 January 2018

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A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning.

21 January 2018

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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

21 January 2018

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Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

21 January 2018

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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

21 January 2018

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Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability

21 January 2018

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12 December 2020

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

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12 December 2020

Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell

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12 December 2020

Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

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12 December 2020

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

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12 December 2020

High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein

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12 December 2020

Identifiers

DOI

10.1038/NATURE07618

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26 November 2017

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