Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells (Q43738757)

26 November 2017

Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells (English)

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26 November 2017

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Chibo Hong

1

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26 November 2017

Gary L Firestone

series ordinal

2

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26 November 2017

Leonard F Bjeldanes

series ordinal

3

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26 November 2017

language of work or name

English

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publication date

1 March 2002

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26 November 2017

Biochemical Pharmacology

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26 November 2017

63

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26 November 2017

6

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26 November 2017

1085-1097

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Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice.

26 November 2017

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Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Antitumour promoting activity of indole-3-carbinol in mouse skin carcinogenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway

7 January 2021

1 reference

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Oligomerization of indole-3-carbinol in aqueous acid

7 January 2021

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Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Ligand-independent activation of estrogen receptor function by 3, 3'-diindolylmethane in human breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

7 January 2021

Regulators of cell death

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis

7 January 2021

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Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

7 January 2021

The Bcl-2 protein family

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Calpain activation in apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Bcl-2 and the regulation of programmed cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Placebo-controlled trial of indole-3-carbinol in the treatment of CIN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2900856-0

Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis

7 January 2021

1 reference

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Bcl-2 overexpression enhances the metastatic potential of a human breast cancer line

7 January 2021

1 reference

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10.1016/S0006-2952(02)00856-0

7 January 2021

Identifiers

DOI

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26 November 2017

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