Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. (Q43762910)

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English	Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity.	scientific article

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12 November 2019

Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity (English)

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12 November 2019

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Michael J. Rogers

7

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12 November 2019

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S Suri

1

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12 November 2019

J Mönkkönen

2

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12 November 2019

M Taskinen

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12 November 2019

J Pesonen

4

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12 November 2019

M A Blank

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12 November 2019

R J Phipps

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12 November 2019

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1 October 2001

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12 November 2019

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12 November 2019

29

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12 November 2019

4

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12 November 2019

336-343

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12 November 2019

Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells

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Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs

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Nonclinical model for assessing gastric effects of bisphosphonates

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7 January 2021

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Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model

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7 January 2021

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Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

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Esophagitis associated with the use of alendronate

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Alendronate induces gastric injury and delays ulcer healing in rodents

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Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

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One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23

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Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

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Effect of bisphosphonates on surface hydrophobicity and phosphatidylcholine concentration of rodent gastric mucosa

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Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

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Pamidronate: an unrecognized problem in gastrointestinal tolerability

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Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase

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