A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span (Q43793707)

26 November 2017

A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span (English)

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Na(+)/H(+) exchanger protein 2 CELE_B0495.4

26 November 2017

Caenorhabditis elegans

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Peptide transporter family 1 CELE_K04E7.2

GOA release 2020-03-11

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GOA release 2020-03-11

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Keith Nehrke

1

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PubMed ID

12939266

26 November 2017

language of work or name

English

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publication date

25 August 2003

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Journal of Biological Chemistry

26 November 2017

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26 November 2017

278

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26 November 2017

45

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26 November 2017

44657-44666

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Na+/H+ exchangers of mammalian cells.

26 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

The NHX family of Na+-H+ exchangers in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Expression cloning of a mammalian proton-coupled oligopeptide transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

H(+)/solute-induced intracellular acidification leads to selective activation of apical Na(+)/H(+) exchange in human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC1 receptor in a human enterocyte-like cell line (Caco-2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

A novel H(+)-coupled oligopeptide transporter (OPT3) from Caenorhabditis elegans with a predominant function as a H(+) channel and an exclusive expression in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

pha-1, a selectable marker for gene transfer in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

The genetics of caloric restriction in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Oxidative stress, caloric restriction, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

The endocrine regulation of aging by insulin-like signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Calcium accelerates endocytosis of vSNAREs at hippocampal synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

In situ measurements of the pH of mammalian peroxisomes using the fluorescent protein pHluorin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Ionic basis of the resting membrane potential and action potential in the pharyngeal muscle of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Calcium dynamics during fertilization in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Modification of cardiac sodium current by intracellular application of cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

H/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na/H exchanger.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na+/H+ exchange activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Distribution and transport of cholesterol in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Role of cholesterol in germ-line development of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Extended life-span conferred by cotransporter gene mutations in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307351200

21 January 2018

Identifiers

DOI

10.1074/JBC.M307351200

1 reference

26 November 2017

1 reference

PubMed ID

12939266