Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition (Q43794066)

26 November 2017

Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition (English)

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26 November 2017

A B Patel

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26 November 2017

D L Rothman

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2

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26 November 2017

G W Cline

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3

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26 November 2017

K L Behar

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4

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26 November 2017

language of work or name

English

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publication date

1 November 2001

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26 November 2017

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26 November 2017

919

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26 November 2017

2

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26 November 2017

207-220

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Glutamate and gamma-aminobutyric acid in brain

26 November 2017

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

GABA as an inhibitory neurotransmitter in human cerebral cortex

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Potentiation of gamma-vinyl GABA (vigabatrin) effects by glycine.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Glutamine--a major substrate for nerve endings.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Increased glutamic acid decarboxylase (GAD) mRNA and GAD activity in cerebellar Purkinje cells following lesion-induced increases in cell firing.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Regulation of gamma-aminobutyric acid synthesis in the brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

First visualization of glutamate and GABA in neurones by immunocytochemistry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Metabolic compartmentation of glutamate associated with the formation of gamma-aminobutyrate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

GABA synthesis in brain slices is dependent on glutamine produced in astrocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Compartmentation of glutamate metabolism in brain. Evidence for the existence of two different tricarboxylic acid cycles in brain

7 January 2021

1 reference

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Glutamine and alpha-ketoglutarate uptake and metabolism by nerve terminal enriched material from mouse cerebellum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Metabolism of lactate in cultured GABAergic neurons studied by 13C nuclear magnetic resonance spectroscopy.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Glutamine and Glucose as Precursors of Transmitter Amino Acids: Ex Vivo Studies

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Glutamate receptors and transporters in genetic and acquired models of epilepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Cerebral metabolism of acetate and glucose studied by 13C-n.m.r. spectroscopy. A technique for investigating metabolic compartmentation in the brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Metabolic precursors and compartmentation of cerebral GABA in vigabatrin-treated rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Pyruvate carboxylase activity in primary cultures of astrocytes and neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Fine structural localization of glutamine synthetase in astrocytes of rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

The flux from glucose to glutamate in the rat brain in vivo as determined by 1H-observed, 13C-edited NMR spectroscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Optimal freezing conditions for cerebral metabolites in rats.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Acid lability of metabolites of 2-deoxyglucose in rat brain: implications for estimates of kinetic parameters of deoxyglucose phosphorylation and transport between blood and brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Polyamine reutilization and turnover in brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Spontaneous release of gamma-aminobutyric acid formed from putrescine and its enhanced Ca2+-dependent release by high K+ stimulation in the brains of freely moving rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Glutamine as precursor for the GABA and glutamate trasmitter pools.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Importance of glutamine for gamma-aminobutyric acid synthesis in rat neostriatum in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Cerebral metabolic compartmentation as revealed by nuclear magnetic resonance analysis of D-[1-13C]glucose metabolism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Localization of neuronal and glial glutamate transporters

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Metabolism and role of glutamate in mammalian brain

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

GABA transporter heterogeneity: pharmacology and cellular localization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Immunoreactivity for the GABA transporter-1 and GABA transporter-3 is restricted to astrocytes in the rat thalamus. A light and electron-microscopic immunolocalization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

GABA metabolism in cultured glial cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

GABAergic system in the developing mammalian retina: dual sources of GABA at early stages of postnatal development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Effects of GABA-transaminase inhibition on brain metabolism and amino-acid compartmentation: an in vivo study by 2D 1H-NMR spectroscopy coupled with microdialysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Two isoforms of glutamate decarboxylase: why?

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

The structural and functional heterogeneity of glutamic acid decarboxylase: A review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

The level of GAD67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Proton MRS in neurological disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

GABA changes with vigabatrin in the developing human brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Effects of vigabatrin intake on brain GABA activity as monitored by spectrally edited magnetic resonance spectroscopy and positron emission tomography.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Effects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C]] glucose with or without ammonium acetate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Glutamine transport in cerebellar granule cells in culture.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Metabolic fate of [14C]-glutamine in mouse cerebral neurons in primary cultures.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Localization of glutaminase in the rat neostriatum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Control of glutaminase activity in rat brain cortex in vitro: influence of glutamate, phosphate, ammonium, calcium and hydrogen ions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Glutaminase in neurons and astrocytes cultured from mouse brain: kinetic properties and effects of phosphate, glutamate, and ammonia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Alterations in Uptake and Release Rates for GABA, Glutamate, and Glutamine During Biochemical Maturation of Highly Purified Cultures of Cerebral Cortical Neurons, a GABAergic Preparation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Developmental change of endogenous glutamate and gamma-glutamyl transferase in cultured cerebral cortical interneurons and cerebellar granule cells, and in mouse cerebral cortex and cerebellum in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Distribution of phosphate-activated glutaminase in the human cerebral cortex.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Histochemistry of glutamate metabolizing enzymes in the rat cerebellar cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Paucity of glutaminase-immunoreactive nonpyramidal neurons in the rat cerebral cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Glutamate-synthesizing enzymes in GABAergic neurons of the neocortex: a double immunofluorescence study in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

The glutamine transaminase-omega-amidase system in rat and human brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

High activities of glutamine transaminase K (dichlorovinylcysteine beta-lyase) and omega-amidase in the choroid plexus of rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

inferred from DOI database lookup

7 January 2021

based on heuristic

A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

inferred from DOI database lookup

7 January 2021

based on heuristic

Neuronal high-affinity glutamate transport in the rat central nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2903015-3

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-8993(01)03015-3

1 reference

26 November 2017

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