Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. (Q43839169)

27 November 2017

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. (English)

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27 November 2017

Saftig P

1

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27 November 2017

Peters C

2

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27 November 2017

von Figura K

3

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27 November 2017

Craessaerts K

4

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27 November 2017

Van Leuven F

5

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27 November 2017

De Strooper B

6

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27 November 2017

language of work or name

English

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publication date

1 November 1996

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Journal of Biological Chemistry

27 November 2017

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27 November 2017

271

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27 November 2017

27241-27244

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27 November 2017

44

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The molecular pathology of Alzheimer's disease

27 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Immunolocalization of cathepsin D in normal and neoplastic human tissues

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Processing of the pre-beta-amyloid protein by cathepsin D is enhanced by a familial Alzheimer's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta A4 amyloid: possible involvement of cathepsin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.44.27241

21 January 2018

Identifiers

DOI

10.1074/JBC.271.44.27241

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27 November 2017

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