Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome (Q43906174)

27 November 2017

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome (English)

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27 November 2017

Jorge Busciglio

1

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27 November 2017

Alejandra Pelsman

2

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27 November 2017

Caine Wong

3

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27 November 2017

Gustavo Pigino

4

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27 November 2017

Menglan Yuan

5

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27 November 2017

Hiroshi Mori

6

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27 November 2017

Bruce A Yankner

7

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27 November 2017

language of work or name

English

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publication date

1 February 2002

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27 November 2017

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27 November 2017

33

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27 November 2017

677-688

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27 November 2017

5

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Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.

27 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Aging, energy, and oxidative stress in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Reduction of neurological damage by a peptide segment of the amyloid beta/A4 protein precursor in a rabbit spinal cord ischemia model

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Activation of a neurofilament kinase, a tau kinase, and a tau phosphatase by decreased ATP levels in nerve growth factor-differentiated PC-12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

A one-hit model of cell death in inherited neuronal degenerations

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

The neurobiologic consequences of Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Transport of vesicular stomatitis virus glycoprotein in a cell-free extract

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Intraneuronal Abeta42 accumulation in human brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

The mitochondrial electron transport and oxidative phosphorylation system

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Mitochondrial abnormalities in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Decreased levels of complex III core protein 1 and complex V beta chain in brains from patients with Alzheimer's disease and Down syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Deposition of beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

The pathological association between Down syndrome and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Mitochondria in neurodegeneration: bioenergetic function in cell life and death

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Early glycoxidation damage in brains from Down's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Selective increase in cellular A beta 42 is related to apoptosis but not necrosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Molecular mapping of Alzheimer-type dementia in Down's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Mitochondrial membrane potential monitored by JC-1 dye.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Diminished glutathione levels cause spontaneous and mitochondria-mediated cell death in neurons from trisomy 16 mice: a model of Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Apoptosis induced by HIV-1 infection of the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

The survival of rat cerebral cortical neurons in the presence of trophic APP peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

10.1016/S0896-6273(02)00604-9

Identifiers

DOI

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27 November 2017

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