Coupling of isoprenoid triflates with organoboron nucleophiles: synthesis and biological evaluation of geranylgeranyl diphosphate analogues (Q43911092)

28 November 2017

title

Coupling of isoprenoid triflates with organoboron nucleophiles: synthesis and biological evaluation of geranylgeranyl diphosphate analogues (English)

1 reference

28 November 2017

4

Richard A Gibbs

1 reference

28 November 2017

YongQi Mu

1

1 reference

28 November 2017

Lisa M Eubanks

series ordinal

2

1 reference

28 November 2017

C Dale Poulter

series ordinal

3

1 reference

28 November 2017

language of work or name

English

0 references

publication date

1 May 2002

1 reference

Bioorganic & Medicinal Chemistry

28 November 2017

published in

1 reference

28 November 2017

volume

10

1 reference

28 November 2017

issue

5

1 reference

28 November 2017

page(s)

1207-1219

1 reference

Protein prenylation: molecular mechanisms and functional consequences

28 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Recent advances in the study of prenylated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Recent studies of the mechanism of protein prenylation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Protein prenyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

p21ras is modified by a farnesyl isoprenoid

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Ras farnesyltransferase: a new therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Different analogues of farnesyl pyrophosphate inhibit squalene synthase and protein:farnesyltransferase to different extents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Farnesyl-derived inhibitors of ras farnesyl transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Solid-phase synthesis of novel inhibitors of farnesyl transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Aromatic carboxylic acids as farnesyl surrogates in farnesylpyrophosphate-based farnesyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Cuprate-Mediated Synthesis and Biological Evaluation of Cyclopropyl- and tert-Butylfarnesyl Diphosphate Analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Grignard-mediated synthesis and preliminary biological evaluation of novel 3-substituted farnesyl diphosphate analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Yeast Protein Geranylgeranyltransferase Type-I: Overproduction, Purification, and Characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Yeast protein geranylgeranyltransferase type-I: steady-state kinetics and substrate binding

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Consequences of altered isoprenylation targets on a-factor export and bioactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Expression and characterization of protein geranylgeranyltransferase type I from the pathogenic yeast Candida albicans and identification of yeast selective enzyme inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Pyridine-derived triflating reagents: An improved preparation of vinyl triflates from metallo enolates

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Stereospecific synthesis and biological evaluation of farnesyl diphosphate isomers

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Practical methylation of aryl halides by Suzuki–Miyaura coupling

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Large rate accelerations in the stille reaction with tri-2-furylphosphine and triphenylarsine as palladium ligands: mechanistic and synthetic implications

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

On the Nature of the "Copper Effect" in the Stille Cross-Coupling

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Analysis and purification of phosphorylated isoprenoids by reversed-phase HPLC

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2801%2900390-X

7 January 2021

10.1016/S0968-0896(01)00390-X

Identifiers

DOI

1 reference

28 November 2017

1 reference