Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates (Q43948608)

28 November 2017

title

Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates (English)

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28 November 2017

John E Reiner

1

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28 November 2017

Daniel V Siev

2

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28 November 2017

Gian Luca Araldi

3

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28 November 2017

Jingrong Jean Cui

4

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28 November 2017

Jonathan Z Ho

5

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28 November 2017

Komandla Malla Reddy

6

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28 November 2017

Lala Mamedova

7

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28 November 2017

Phong H Vu

8

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28 November 2017

Kuen Shan S Lee

9

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28 November 2017

Nathaniel K Minami

10

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28 November 2017

Tony S Gibson

11

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28 November 2017

Susanne M Anderson

12

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28 November 2017

Annette E Bradbury

13

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28 November 2017

Thomas G Nolan

14

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28 November 2017

J Edward Semple

15

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28 November 2017

language of work or name

English

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publication date

1 April 2002

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28 November 2017

number of pages

6

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Bioorganic & Medicinal Chemistry Letters

inferred from page(s)

published in

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28 November 2017

volume

12

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28 November 2017

issue

8

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28 November 2017

page(s)

1203-1208

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New advances in the discovery of thrombin and factor Xa inhibitors

28 November 2017

cites work

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Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors

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Structural basis of the thrombin selectivity of a ligand that contains the constrained arginine mimic (2S)-2-amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic acid at P1

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7 January 2021

Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on so

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7 January 2021

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position

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7 January 2021

The design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors

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7 January 2021

Asymmetric synthesis of novel quaternary alpha-hydroxy-delta-lactam dipeptide surrogates

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7 January 2021

Investigation of the S3 site of thrombin: design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P1-argininals

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7 January 2021

Alkoxide-catalyzed ring-opening of a novel homosaccharin derivative: synthesis of potent, selective P3-lactam thrombin inhibitors containing P4-o-alkoxycarbonylbenzylsulfonamide residues.

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7 January 2021

Potent and selective thrombin inhibitors featuring hydrophobic, basic P3-P4-aminoalkyllactam moieties

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7 January 2021

Design and construction of novel thrombin inhibitors featuring P3-P4 quaternary lactam dipeptide surrogates

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7 January 2021

Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties

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7 January 2021

Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa

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7 January 2021

Exploratory solid-phase synthesis of factor Xa inhibitors: discovery and application of p3-heterocyclic amides as novel types of non-basic arginine surrogates

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7 January 2021

Novel benzo-fused lactam scaffolds as factor Xa inhibitors

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7 January 2021

Novel, potent non-covalent thrombin inhibitors incorporating p(3)-lactam scaffolds

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7 January 2021

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor

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7 January 2021

Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates

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7 January 2021

Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties

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7 January 2021

Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes

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7 January 2021

Active site-directed thrombin inhibitors-II. Studies related to arginine/guanidine bioisosteres

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7 January 2021

The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900129-4

7 January 2021

10.1016/S0960-894X(02)00129-4

Identifiers

DOI

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28 November 2017

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