Cysteine-scanning mutagenesis reveals a conformationally sensitive reentrant pore-loop in the glutamate transporter GLT-1. (Q43982363)

28 November 2017

Cysteine-scanning mutagenesis reveals a conformationally sensitive reentrant pore-loop in the glutamate transporter GLT-1. (English)

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28 November 2017

Myriam Grunewald

1

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28 November 2017

David Menaker

series ordinal

2

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28 November 2017

Baruch I Kanner

series ordinal

3

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28 November 2017

language of work or name

English

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publication date

6 May 2002

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Journal of Biological Chemistry

28 November 2017

7

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based on heuristic

inferred from page(s)

published in

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28 November 2017

277

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28 November 2017

29

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28 November 2017

26074-26080

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The release and uptake of excitatory amino acids

28 November 2017

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Flux coupling in a neuronal glutamate transporter

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Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

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Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

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Glial contributions to excitatory neurotransmission in cultured hippocampal cells.

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Active transport of L-glutamate by membrane vesicles isolated from rat brain

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Kinetics of a human glutamate transporter.

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Binding order of substrates to the (sodium + potassium ion)-coupled L-glutamic acid transporter from rat brain

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Counterflow of L-glutamate in plasma membrane vesicles and reconstituted preparations from rat brain.

21 January 2018

1 reference

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Ion fluxes associated with excitatory amino acid transport.

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An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

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Cloning and expression of a rat brain L-glutamate transporter

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Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain

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Primary structure and functional characterization of a high-affinity glutamate transporter

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Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

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Biotinylation of single cysteine mutants of the glutamate transporter GLT-1 from rat brain reveals its unusual topology.

21 January 2018

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A conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop

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Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter

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Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter

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Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

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Cysteine scanning of the surroundings of an alkali-ion binding site of the glutamate transporter GLT-1 reveals a conformationally sensitive residue.

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Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

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On the use of thiol-modifying agents to determine channel topology

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

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Structural determinants of water permeation through aquaporin-1

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Structure of a glycerol-conducting channel and the basis for its selectivity

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Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis

21 January 2018

1 reference

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Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

21 January 2018

1 reference

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Cysteine-scanning mutagenesis reveals a highly amphipathic, pore-lining membrane-spanning helix in the glutamate transporter GltT.

21 January 2018

1 reference

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Mechanism of Transport and Storage of Neurotransmitter

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Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells

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21 January 2018

Identifiers

DOI

10.1074/JBC.M202248200

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28 November 2017

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