Nucleolar disruption and cajal body disassembly are nuclear hallmarks of DNA damage-induced neurodegeneration in purkinje cells (Q43983188)

28 November 2017

Nucleolar disruption and cajal body disassembly are nuclear hallmarks of DNA damage-induced neurodegeneration in purkinje cells (English)

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28 November 2017

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28 November 2017

Fernando C Baltanás

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28 November 2017

Eduardo Weruaga

3

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28 November 2017

José R Alonso

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28 November 2017

María T Berciano

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28 November 2017

Miguel Lafarga

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28 November 2017

language of work or name

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30 November 2010

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28 November 2017

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28 November 2017

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28 November 2017

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28 November 2017

374-388

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Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage.

28 November 2017

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

PML enhances the regulation of p53 by CK1 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Cajal body number and nucleolar size correlate with the cell body mass in human sensory ganglia neurons

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Retinal degeneration in the pcd cerebellar mutant mouse. II. Electron microscopic analysis.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The multifunctional nucleolus

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

CAJAL BODIES: A Long History of Discovery

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

UV-induced fragmentation of Cajal bodies.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Purkinje cell death: differences between developmental cell death and neurodegenerative death in mutant mice.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Mutant huntingtin impairs Ku70-mediated DNA repair

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

H2AX: the histone guardian of the genome

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Cajal bodies: the first 100 years

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Mitral cell degeneration and sensory function in the neurological mutant mouse Purkinje cell degeneration (PCD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Inhibition of nucleolar transcription as a trigger for neuronal apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Steroid-triggered programmed cell death of a motoneuron is autophagic and involves structural changes in mitochondria

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

p53 localizes to intranucleolar regions distinct from the ribosome production compartments.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Apoptosis induced by methylazoxymethanol in developing rat cerebellum: organization of the cell nucleus and its relationship to DNA and rRNA degradation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Cajal's contribution to the knowledge of the neuronal cell nucleus

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Nuclear speckles: a model for nuclear organelles

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The development and degeneration of Purkinje cells inpcd mutant mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Correlation between severity and SMN protein level in spinal muscular atrophy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Disassembly of nuclear bodies during arousal from hibernation: an in vitro study.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

DNA damage and repair: relevance to mechanisms of neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The Cajal body and histone locus body

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Degeneration of thalamic neurons in "Purkinje cell degeneration" mutant mice. I. Distribution of neuron loss.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

In search of nonribosomal nucleolar protein function and regulation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Stress-induced activation of c-Jun N-terminal kinase in sensory ganglion neurons: accumulation in nuclear domains enriched in splicing factors and distribution in perichromatin fibrils.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Neuronal body size correlates with the number of nucleoli and Cajal bodies, and with the organization of the splicing machinery in rat trigeminal ganglion neurons

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

New insights into nucleolar architecture and activity.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Defective DNA repair and neurodegenerative disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Protein-protein interaction networks in the spinocerebellar ataxias

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Does the ribosome translate cancer?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The aging brain: accumulation of DNA damage or neuron loss?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Nucleolus: the fascinating nuclear body

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The Cajal body: a meeting place for spliceosomal snRNPs in the nuclear maze

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Pre-neurodegeneration of mitral cells in the pcd mutant mouse is associated with DNA damage, transcriptional repression, and reorganization of nuclear speckles and Cajal bodies.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The Purkinje cell degeneration (pcd) mouse: an unexpected molecular link between neuronal degeneration and regeneration

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

Repression of RNA polymerase I transcription by the tumor suppressor p53

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2010.00461.X

10.1111/J.1750-3639.2010.00461.X

21 January 2018

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DOI

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28 November 2017

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