Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding. (Q44009139)

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scientific article published in May 2002

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English	Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding.	scientific article published in May 2002

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scholarly article

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9 November 2019

Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding (English)

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9 November 2019

Plasmodium falciparum

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inferred from title

mutational analysis

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Giulio Rastelli

5

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9 November 2019

Yongyuth Yuthavong

7

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9 November 2019

Sumalee Kamchonwongpaisan

6

object named as

Sumalee Kamchonwongpaisan

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9 November 2019

author name string

Worachart Sirawaraporn

1

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9 November 2019

Rachada Sirawaraporn

2

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9 November 2019

Suganya Yongkiettrakul

3

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9 November 2019

Amornpol Anuwatwora

4

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9 November 2019

publication date

1 May 2002

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9 November 2019

Molecular and Biochemical Parasitology

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9 November 2019

121

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9 November 2019

2

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9 November 2019

185-193

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9 November 2019

Dihydrofolate reductase and antifolate resistance in malaria

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Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building.

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Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance

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A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors

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Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state

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13C and 15N nuclear magnetic resonance evidence that the active site carboxyl group of dihydrofolate reductase is not involved in the relay of a proton to substrate

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Crystal structure of human dihydrofolate reductase complexed with folate

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Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

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Effects of distal point-site mutations on the binding and catalysis of dihydrofolate reductase from Escherichia coli

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Hydrophobic interactions via mutants of Escherichia coli dihydrofolate reductase: separation of binding and catalysis.

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Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis

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How do mutations at phenylalanine-153 and isoleucine-155 partially suppress the effects of the aspartate-27-->serine mutation in Escherichia coli dihydrofolate reductase?

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Dihydrofolate reductase mutations and chromosomal changes associated with pyrimethamine resistance of Plasmodium falciparum

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Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

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Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

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Dihydrofolate reductase from Escherichia coli: probing the role of aspartate-27 and phenylalanine-137 in enzyme conformation and the binding of NADPH

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Identifiers

10.1016/S0166-6851(02)00035-X

1 reference

Europe PubMed Central

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9 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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