Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease (Q44013447)

28 November 2017

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease (English)

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28 November 2017

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28 November 2017

Jin Xu

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author name string

Shyan-Yuan Kao

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28 November 2017

Frank J S Lee

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Lee-Way Jin

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28 November 2017

Bruce A Yankner

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language of work or name

English

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publication date

1 June 2002

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28 November 2017

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600-606

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https://scigraph.springernature.com/pub.10.1038/nm0602-600

28 November 2017

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cites work

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

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Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

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Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

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A Drosophila model of Parkinson's disease

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

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Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

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alpha-Synuclein affects the MAPK pathway and accelerates cell death

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14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains

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Apoptosis in the nervous system

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

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Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

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Glutathione is involved in the granular storage of dopamine in rat PC 12 pheochromocytoma cells: implications for the pathogenesis of Parkinson's disease.

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Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

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The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

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Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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Contribution of somal Lewy bodies to neuronal death.

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Selection for neuroblastoma cells that synthesize certain transmitters

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Identifiers

DOI

10.1038/NM0602-600

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Dimensions Publication ID

28 November 2017

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