The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form (Q44019111)

29 November 2017

The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form (English)

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29 November 2017

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29 November 2017

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29 November 2017

Jørgen Kjems

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PubMed ID

12051861

29 November 2017

language of work or name

English

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publication date

1 April 2002

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Journal of Molecular Biology

29 November 2017

11

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based on heuristic

inferred from page(s)

published in

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29 November 2017

318

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29 November 2017

2

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29 November 2017

583-593

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RanGAP1 induces GTPase activity of nuclear Ras-related Ran

29 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

The ran GTPase regulates mitotic spindle assembly.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Transport between the cell nucleus and the cytoplasm

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Importins and exportins: how to get in and out of the nucleus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

NTF2 mediates nuclear import of Ran.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Nuclear import of Ran is mediated by the transport factor NTF2.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Role of importin-beta in coupling Ran to downstream targets in microtubule assembly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Structural view of the Ran-Importin beta interaction at 2.3 A resolution

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

A novel class of RanGTP binding proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Identification of a tRNA-specific nuclear export receptor

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Dissecting the interactions between NTF2, RanGDP, and the nucleoporin XFXFG repeats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Mutations within the Ran/TC4 GTPase. Effects on regulatory factor interactions and subcellular localization

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

A role for the basic patch and the C terminus of RanGTP in regulating the dynamic interactions with importin beta, CRM1 and RanBP1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Selective disruption of nuclear import by a functional mutant nuclear transport carrier

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

Isolation of a protein that is essential for the first step of nuclear protein import

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

The direction of transport through the nuclear pore can be inverted

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900040-2

10.1016/S0022-2836(02)00040-2

7 January 2021

Identifiers

DOI

1 reference

29 November 2017

1 reference

PubMed ID

12051861