Peroxisome proliferator-activated receptor alpha,gamma coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice (Q44022178)

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English	Peroxisome proliferator-activated receptor alpha,gamma coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

29 November 2017

Peroxisome proliferator-activated receptor alpha,gamma coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice (English)

1 reference

Europe PubMed Central

29 November 2017

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atherosclerosis

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based on heuristic

inferred from title

author name string

Steven H Zuckerman

1

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Europe PubMed Central

29 November 2017

Raymond F Kauffman

2

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Europe PubMed Central

29 November 2017

Glenn F Evans

3

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Europe PubMed Central

29 November 2017

publication date

1 May 2002

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Europe PubMed Central

29 November 2017

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Europe PubMed Central

29 November 2017

37

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Europe PubMed Central

29 November 2017

5

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Europe PubMed Central

29 November 2017

487-494

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Europe PubMed Central

29 November 2017

https://scigraph.springernature.com/pub.10.1007/s11745-002-0922-2

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Estrogen-mediated increases in LDL cholesterol and foam cell-containing lesions in human ApoB100xCETP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics

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https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

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https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine regulation of macrophage apo E secretion: opposing effects of GM-CSF and TGF-beta

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https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

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inferred from PubMed ID database lookup

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice

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https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

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inferred from PubMed ID database lookup

CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated Receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells.

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https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

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Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

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https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-mediated immunity in atherosclerosis.

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https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

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Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the macrophage scavenger receptor in atheroma. Relationship to immune activation and the T-cell cytokine interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The emergence of mouse models of atherosclerosis and their relevance to clinical research

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

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Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nuclear receptor superfamily: the second decade

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic inflammatory parameters in patients with atherosclerosis of the coronary and peripheral arteries

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

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inferred from PubMed ID database lookup

Macrophages and atherosclerotic plaque stability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of gamma-interferon to inhibit macrophage-high density lipoprotein interactions is reversed by 15-deoxy-delta12,14-prostaglandin J2

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis — An Inflammatory Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular responses to interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis: from lesion formation to plaque activation and endothelial dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cholesterol distribution in macrophage-derived foam cells by interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peroxisome proliferator-activated receptor(PPARgamma) as a regulator of monocyte/macrophage function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular and genetic dissection of the retinoid signaling pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma induces downregulation of Tangier disease gene (ATP-binding-cassette transporter 1) in macrophage-derived foam cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cholesteryl ester transfer protein in normocholesterolemic and hypercholesterolemic hamsters: effects on HDL subspecies, quantity, and apolipoprotein distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

1 reference

https://pubmed.ncbi.nlm.nih.gov/12056591

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11745-002-0922-2

1 reference

Europe PubMed Central

29 November 2017

1 reference

Europe PubMed Central

29 November 2017

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