Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution? (Q44029222)

29 November 2017

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title

Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution? (English)

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29 November 2017

Frank Kirchhoff

1

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language of work or name

English

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publication date

23 March 2009

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Nature Reviews Microbiology

29 November 2017

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29 November 2017

7

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29 November 2017

467-476

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29 November 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrmicro2111

29 November 2017

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Naturally SIV-infected sooty mangabeys: are we closer to understanding why they do not develop AIDS?

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

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Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway

31 March 2020

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HIV-1 Nef increases T cell activation in a stimulus-dependent manner

31 March 2020

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The Nef protein of HIV-1 associates with rafts and primes T cells for activation

31 March 2020

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31 March 2020

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Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Hybrid origin of SIV in chimpanzees.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus

31 March 2020

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Th-1-type cytotoxic CD8+ T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeys

31 March 2020

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Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Down-modulation of the costimulatory molecule, CD28, is a conserved activity of multiple SIV Nefs and is dependent on histidine 196 of Nef.

31 March 2020

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Mechanism for down-regulation of CD28 by Nef.

31 March 2020

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Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.

31 March 2020

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Simian immunodeficiency virus SIVagm dynamics in African green monkeys

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRMICRO2111

Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis

31 March 2020

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Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions

31 March 2020

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Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2111

T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2111

Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hosts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2111

Presence of Intact vpu and nef genes in nonpathogenic SHIV is essential for acquisition of pathogenicity of this virus by serial passage in macaques

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2111

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2111

Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2111

Intrinsic immunity: a front-line defense against viral attack

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2111

Intracellular restriction factors in mammalian cells--An ancient defense system finds a modern foe.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2111

The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses.

31 March 2020

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12 December 2020

What can natural infection of African monkeys with simian immunodeficiency virus tell us about the pathogenesis of AIDS?

1 reference

12 December 2020

Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections

1 reference

12 December 2020

HIV type 1 Nef increases the association of T cell receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion

1 reference

12 December 2020

Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1

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12 December 2020

Diverse host responses and outcomes following simian immunodeficiency virus SIVmac239 infection in sooty mangabeys and rhesus macaques.

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12 December 2020

Loss of CD4+ T cells in human immunodeficiency virus type 1-infected chimpanzees is associated with increased lymphocyte apoptosis

1 reference

12 December 2020

The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.

1 reference

12 December 2020

Induction of AIDS in rhesus monkeys by a recombinant simian immunodeficiency virus expressing nef of human immunodeficiency virus type 1.

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12 December 2020

Identifiers

DOI

10.1038/NRMICRO2111

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29 November 2017

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PubMed ID

19305418