Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. (Q44035580)

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10 November 2019

title

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours (English)

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10 November 2019

1

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10 November 2019

author name string

Rob A van der Kammen

2

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10 November 2019

Kristopher Clark

3

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10 November 2019

Maarten van der Valk

4

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10 November 2019

Frits Michiels

5

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10 November 2019

John G Collard

6

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10 November 2019

language of work or name

English

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publication date

1 June 2002

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10 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12075356%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

volume

417

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10 November 2019

page(s)

867-871

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10 November 2019

issue

6891

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https://scigraph.springernature.com/pub.10.1038/nature00848

10 November 2019

exact match

0 references

cites work

Rho GTPases and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Ras and Rho GTPases: a family reunion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

An essential role for Rac in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

A role for Rac in Tiam1-induced membrane ruffling and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis.

21 January 2018

1 reference

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Integration of positive and negative growth signals during ras pathway activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Suppression of Ras-induced apoptosis by the Rac GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

A causal role for E-cadherin in the transition from adenoma to carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00848

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE00848

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12075356%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 November 2019

0 references

1 reference