The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma (Q44043146)

29 November 2017

title

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma (English)

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29 November 2017

1

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29 November 2017

James R Vasselli

2

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29 November 2017

Joseph Riss

3

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29 November 2017

Juan S Bonifacino

4

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29 November 2017

W Marston Linehan

5

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29 November 2017

Richard D Klausner

6

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29 November 2017

publication date

1 April 2002

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29 November 2017

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29 November 2017

volume

1

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29 November 2017

issue

3

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29 November 2017

page(s)

247-255

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Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

29 November 2017

cites work

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

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7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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7 January 2021

Cloning and expression pattern of EPAS1 in the chicken embryo. Colocalization with tyrosine hydroxylase

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7 January 2021

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

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7 January 2021

Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha

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7 January 2021

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

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Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

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7 January 2021

Mutations of the VHL tumour suppressor gene in renal carcinoma

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7 January 2021

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

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7 January 2021

Tumour suppression by the human von Hippel-Lindau gene product

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7 January 2021

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

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7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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7 January 2021

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

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7 January 2021

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

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7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

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7 January 2021

Improved methods of retroviral vector transduction and production for gene therapy

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7 January 2021

Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death

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7 January 2021

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

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7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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7 January 2021

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

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7 January 2021

Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

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7 January 2021

Complex role of protein phosphorylation in gene activation by hypoxia

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7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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7 January 2021

Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1.

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7 January 2021

Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells

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7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

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7 January 2021

The HIF pathway: implications for patterns of gene expression in cancer.

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7 January 2021

10.1016/S1535-6108(02)00044-2

Identifiers

DOI

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29 November 2017

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