John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity (Q44091038)

29 November 2017

John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity (English)

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29 November 2017

Erik De Clercq

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publication date

1 January 2005

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Nucleosides, Nucleotides & Nucleic Acids

29 November 2017

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29 November 2017

24

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29 November 2017

10-12

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29 November 2017

1395-1415

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Broad-spectrum antiviral activity of the carbocyclic analog of 3-deazaadenosine

29 November 2017

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https://api.crossref.org/works/10.1080%2F15257770500265638

Broad-spectrum antiviral activity of adenosine analogues

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770500265638

S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Correlation between the antiviral activity of acyclic and carbocyclic adenosine analogues in murine L929 cells and their inhibitory effect on L929 cells S-adenosylhomocysteine hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Influence of S-adenosylhomocysteine hydrolase inhibitors on S-adenosylhomocysteine and S-adenosylmethionine pool levels in L929 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at S-adenosylhomocysteine hydrolase.

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770500265638

Antiviral activity of aliphatic nucleoside analogues: structure-function relationship

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770500265638

Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770500265638

Antiviral and antimetabolic activities of neplanocins

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770500265638

Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770500265638

Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

9-(trans-2',trans-3'-Dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Antiviral enantiomeric preference for 5'-noraristeromycin.

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770500265638

3-deaza- and 7-deaza-5'-noraristeromycin and their antiviral properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

New neplanocin analogues. VIII. Synthesis and biological activity of 6'-C-ethyl, -ethenyl, and -ethynyl derivatives of neplanocin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

An epimer of 5'-noraristeromycin and its antiviral properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

A mercapto analogue of 5'-noraristeromycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its "hydrolytic activity": synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Sugar-modified conjugated diene analogues of adenosine and uridine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

S-adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Antiviral and antimetabolic activities of formycin and its N1-, N2-, 2'-O- and 3'-O-methylated derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Inhibitory effect of selected antiviral compounds on arenavirus replication in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Activity of several S-adenosylhomocysteine hydrolase inhibitors against African swine fever virus replication in Vero cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Inhibitory activity of S-adenosylhomocysteine hydrolase inhibitors against human cytomegalovirus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Comparative efficacy of broad-spectrum antiviral agents as inhibitors of rotavirus replication in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Antiviral activities of ribavirin, 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide, and 6'-(R)-6'-C-methylneplanocin A against several ortho- and paramyxoviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Inhibition of measles virus replication by 5'-nor carbocyclic adenosine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Inhibitory effect of selected antiviral compounds on measles (SSPE) virus replication in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Inhibitory effects of antiviral compounds on respiratory syncytial virus replication in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Tat stimulates cotranscriptional capping of HIV mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

THE FORMATION OF S-ADENOSYLHOMOCYSTEINE IN ENZYMATIC TRANSMETHYLATION REACTIONS1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Trypanosoma cruzi: molecular cloning and characterization of the S-adenosylhomocysteine hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

The importance of the 4'-hydroxyl hydrogen for the anti-trypanosomal and antiviral properties of (+)-5'-noraristeromycin and two 7-deaza analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Synthesis of 2-fluoronoraristeromycin and its inhibitory activity against Plasmodium falciparum S-Adenosyl-l-homocysteine hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Cloning of the gene encoding Leishmania donovani S-adenosylhomocysteine hydrolase, a potential target for antiparasitic chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

Antivirals and antiviral strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770500265638

10.1080/15257770500265638

21 January 2018

Identifiers

DOI

1 reference

29 November 2017

1 reference

PubMed ID

16438025