Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations. (Q44109092)

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12 November 2019

title

Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations (English)

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12 November 2019

13

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Raymond W Tennant

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12 November 2019

author name string

Hisham K Hamadeh

1

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12 November 2019

Brian L Knight

2

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12 November 2019

Astrid C Haugen

3

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12 November 2019

Stella Sieber

4

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12 November 2019

Rupesh P Amin

5

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12 November 2019

Pierre R Bushel

6

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12 November 2019

Raymond Stoll

7

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12 November 2019

Kerry Blanchard

8

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12 November 2019

Supriya Jayadev

9

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12 November 2019

Michael L Cunningham

11

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12 November 2019

Cynthia A Afshari

12

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language of work or name

English

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publication date

1 July 2002

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12 November 2019

published in

Toxicologic Pathology

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12 November 2019

volume

30

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12 November 2019

page(s)

470-482

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12 November 2019

issue

4

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14-Week toxicity and cell proliferation of methyleugenol administered by gavage to F344 rats and B6C3F1 mice

12 November 2019

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The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice.

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Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay.

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The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats.

21 January 2018

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Effects of methapyrilene measured in mitochondria isolated from naive and methapyrilene-treated rat and mouse hepatocytes

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Cluster analysis and display of genome-wide expression patterns

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Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.

21 January 2018

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Two-year toxicity and carcinogenicity study of methyleugenol in F344/N rats and B6C3F(1) mice.

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Species differences in the in vitro metabolism of methapyrilene

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The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells

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Species differences in the metabolism and macromolecular binding of methapyrilene: a comparison of rat, mouse and hamster

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Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride

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Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI.

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Genotoxicity, toxicity, and carcinogenicity of the antihistamine methapyrilene

21 January 2018

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The evaluation of methapyrilene for bacterial mutation with metabolic activation by Aroclor-induced, methapyrilene-induced and noninduced rat-liver S9.

21 January 2018

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4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implications

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Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein

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Role of lipids, lipoproteins and vitamins in women with breast cancer

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Ultrastructural changes in the liver of animals treated with methapyrilene and some analogs.

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Effects of methapyrilene on DNA synthesis in mice and rats following continuous dietary exposure

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A comparison of in vivo and in vitro metabolites of the H1-antagonist N,N-dimethyl-N'-2-pyridyl-N'-(2-thienylmethyl)-1,2-ethanediamine (methapyrilene) in the rat.

21 January 2018

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Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene

21 January 2018

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Identification and characterization of a novel gene (neurorep 1) expressed in nerve cells and up-regulated after axotomy

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Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity

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Identifiers

DOI

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12 November 2019

1 reference