Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors. (Q44112148)

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scientific article published in January 2002

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English	Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors.	scientific article published in January 2002

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12 November 2019

Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors (English)

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12 November 2019

neurotransmitter

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3

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12 November 2019

Rafael Rodríguez-Puertas

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12 November 2019

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González-Maeso J

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12 November 2019

García-Sevilla JA

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12 November 2019

Guimón J

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1 January 2002

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12 November 2019

Molecular Psychiatry

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12 November 2019

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12 November 2019

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12 November 2019

755-767

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12 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.mp.4001067

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Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior

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Role of norepinephrine in the pathophysiology and treatment of mood disorders

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Pathophysiology of the locus coeruleus in suicide.

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Neural circuits mediating stress

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Presynaptic Receptors

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Interactions between the presynaptic alpha2-autoreceptor and presynaptic inhibitory heteroreceptors on noradrenergic neurones

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Alpha 2-adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression.

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21 January 2018

Brain alpha-adrenoceptors in depressed suicides.

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21 January 2018

Up-regulation of immunolabeled alpha2A-adrenoceptors, Gi coupling proteins, and regulatory receptor kinases in the prefrontal cortex of depressed suicides.

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21 January 2018

Effect of chronic administration of antidepressants on alpha 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography.

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21 January 2018

Electrophysiologic evidence for desensitization of alpha 2-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentration.

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Activation and desensitization by cyclic antidepressant drugs of alpha2-autoreceptors, alpha2-heteroreceptors and 5-HT1A-autoreceptors regulating monamine synthesis in the rat brain in vivo.

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Chronic treatment with reboxetine by osmotic pumps facilitates its effect on extracellular noradrenaline and may desensitize alpha(2)-adrenoceptors in the prefrontal cortex

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Biochemical and functional evidence of supersensitive platelet alpha 2-adrenoceptors in major affective disorder. Effect of long-term lithium carbonate treatment

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Noradrenergic dysfunction in the prefrontal cortex in depression: an [15O] H2O PET study of the neuromodulatory effects of clonidine

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Diversity and selectivity of receptor-G protein interaction

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Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder

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Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims

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Effects of the alkylating agent EEDQ on regulatory G proteins and recovery of agonist and antagonist alpha2-adrenoceptor binding sites in rat brain.

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Autoradiography of receptor-activated G-proteins in post mortem human brain

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Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes

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Receptor-mediated and receptor-independent activation of G-proteins in rat brain membranes.

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Increased density of guanine nucleotide-binding proteins in the postmortem brains of heroin addicts.

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Data normalization before statistical analysis: keeping the horse before the cart

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Suicidal behavior in bipolar and unipolar affective disorders: a meta-analysis

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Quantitative autoradiography of alpha 1- and alpha 2-adrenergic receptors in the cerebral cortex of controls and suicide victims

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Brain noradrenergic receptors in major depression and schizophrenia.

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Regional distribution of alpha 2A- and alpha 2B-adrenoceptor subtypes in postmortem human brain

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Alpha 2-adrenoceptor subtypes in the human brain: a pharmacological delineation of [3H]RX-821002 binding to membranes and tissue sections.

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Quantitative subregional distribution of serotonin1A receptors and serotonin transporters in the human dorsal raphe.

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5-HT1A Receptors in major depression.

1 reference

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Brain 5-HT1A, 5-HT1D, and 5-HT2 receptors in suicide victims.

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Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims.

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Brain Serotonin1A Receptor Binding Measured by Positron Emission Tomography With [11C]WAY-100635

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Muscarinic binding in suicides

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Cholinergic receptor binding in the frontal cortex of suicide victims

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Brain GABAB binding sites in depressed suicide victims

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Regionally selective increases in mu opioid receptor density in the brains of suicide victims

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Increased density of mu-opioid receptors in the postmortem brain of suicide victims

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Acute and chronic effects of desipramine and clorgyline on alpha(2)-adrenoceptors regulating noradrenergic transmission in the rat brain: a dual-probe microdialysis study

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Inadequate treatment for major depression both before and after attempted suicide.

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Postmortem cerebral cortex Gs alpha-subunit levels are elevated in bipolar affective disorder.

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G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death.

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Subclassification of release-regulating alpha 2-autoreceptors in human brain cortex

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Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan.

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Relapse of depression after rapid depletion of tryptophan.

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Suicide in Subtypes of Major Affective Disorder

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Fewer pigmented locus coeruleus neurons in suicide victims: Preliminary results

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Increased alpha 2-adrenoceptor density in the frontal cortex of depressed suicide victims

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Autoradiographic demonstration of increased alpha 2-adrenoceptor agonist binding sites in the hippocampus and frontal cortex of depressed suicide victims.

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Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims.

1 reference

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7 January 2021

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Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide

1 reference

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alpha 2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment

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Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression. Effect of long-term cyclic antidepressant drug treatment

1 reference

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G protein-coupled receptor kinases

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7 January 2021

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Imbalance of the Gs and Gi/o function in post-mortem human brain of depressed patients

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects.

1 reference

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7 January 2021

based on heuristic

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Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain

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Characterization of receptor-mediated [35S]GTPgammaS binding to cortical membranes from postmortem human brain

1 reference

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Mental illness and suicide. A case-control study in east Taiwan

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Evaluation of studies on platelet alpha 2 adrenoreceptors in depressive illness

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Alpha 2-adrenoceptor subtypes identified by [3H]RX821002 binding in the human brain: the agonist guanoxabenz does not discriminate different forms of the predominant alpha 2A subtype

1 reference

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7 January 2021

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1 reference

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Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims

1 reference

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7 January 2021

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5-HT1A receptor binding sites in post-mortem brain samples from depressed suicides and controls

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Serotonin receptors in suicide victims with major depression

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Platelet I1-imidazoline binding sites are elevated in depression but not generalized anxiety disorder

1 reference

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7 January 2021

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Antidepressants, depression and suicide: an analysis of the San Diego study

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7 January 2021

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Somatodendritic alpha2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine.

1 reference

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7 January 2021

based on heuristic

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Reduced levels of norepinephrine transporters in the locus coeruleus in major depression.

1 reference

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7 January 2021

based on heuristic

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Elevated tyrosine hydroxylase in the locus coeruleus of suicide victims.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression

1 reference

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7 January 2021

based on heuristic

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Endogenous noradrenaline activates alpha 2-adrenoceptors on serotonergic nerve endings in human and rat neocortex.

1 reference

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Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder

1 reference

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Transient Depressive Relapse Induced by Catecholamine Depletion

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based on heuristic

inferred from DOI database lookup

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10.1038/SJ.MP.4001067

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12192620%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12192620%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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