Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway (Q44121094)

30 November 2017

Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway (English)

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30 November 2017

L Eric Huang

1

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30 November 2017

Erin A Pete

2

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30 November 2017

Maureen Schau

3

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30 November 2017

Justine Milligan

4

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30 November 2017

Jie Gu

5

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30 November 2017

language of work or name

English

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publication date

29 August 2002

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Journal of Biological Chemistry

30 November 2017

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30 November 2017

277

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30 November 2017

44

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30 November 2017

41750-41755

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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

30 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

HIF-1 and tumor progression: pathophysiology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Purification and characterization of hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Inhibition of transcription elongation by the VHL tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

An essential role for p300/CBP in the cellular response to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Oxygen sensing and molecular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

The VHL tumour-suppressor gene paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207280200

21 January 2018

Identifiers

DOI

10.1074/JBC.M207280200

1 reference

30 November 2017

1 reference