Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. (Q44132630)

30 November 2017

Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity (English)

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12 May 2020

author name string

Jianren Mao

series ordinal

1

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12 May 2020

Backil Sung

series ordinal

2

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Grewo Lim

series ordinal

4

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language of work or name

English

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publication date

1 September 2002

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30 November 2017

Journal of Neuroscience

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volume

22

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issue

18

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page(s)

8312-8323

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Substrate turnover by transporters curtails synaptic glutamate transients.

12 May 2020

cites work

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12 December 2020

Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor

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12 December 2020

Role of protein kinase C in desensitization of spinal delta-opioid-mediated antinociception in the mouse

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Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo.

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Protein kinase C modulates NMDA receptor trafficking and gating

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NMDA and opioid receptors: their interactions in antinociception, tolerance and neuroplasticity

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Repetitive opioid abstinence causes progressive hyperalgesia sensitive to N-methyl-D-aspartate receptor blockade in the rat.

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Opioid tolerance-in search of the holy grail

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Chronic catheterization of the spinal subarachnoid space.

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Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn

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Morphine-activated opioid receptors elude desensitization by beta-arrestin

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12 December 2020

Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine

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12 December 2020

Effect of transient naloxone antagonism on tolerance development in rats receiving continuous spinal morphine infusion

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12 December 2020

Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain.

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12 December 2020

Enhanced morphine analgesia in mice lacking beta-arrestin 2

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12 December 2020

Increased analgesic potency of mu agonists after continuous naloxone infusion in rats

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Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: impact on gliogenesis in vivo

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Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

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Down-regulation of mu-opioid receptor expression in rat oligodendrocytes during their development in vitro

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12 December 2020

Regional, developmental, and cell cycle-dependent differences in mu, delta, and kappa-opioid receptor expression among cultured mouse astrocytes

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12 December 2020

Regional deafferentation down-regulates subtypes of glutamate transporter proteins

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12 December 2020

Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin.

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Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process

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12 December 2020

Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice

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12 December 2020

The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1

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12 December 2020

Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C.

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12 December 2020

Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal

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Drug addictions. Molecular and cellular endpoints.

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12 December 2020

Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death

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12 December 2020

Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions.

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12 December 2020

Tolerance to morphine at the mu-opioid receptor differentially induced by cAMP-dependent protein kinase activation and morphine

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12 December 2020

Role of cAMP-dependent protein kinase (PKA) in opioid agonist-induced mu-opioid receptor downregulation and tolerance in mice

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12 December 2020

Identification of morphine- and cyclic AMP-regulated phosphoproteins (MARPPs) in the locus coeruleus and other regions of rat brain: regulation by acute and chronic morphine

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12 December 2020

Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization

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12 December 2020

Enzymatic degradation protects neurons from glutamate excitotoxicity

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12 December 2020

Spinal amino acid release and precipitated withdrawal in rats chronically infused with spinal morphine

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12 December 2020

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

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12 December 2020

Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats

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12 December 2020

Molecular mechanisms of drug addiction

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12 December 2020

The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive.

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12 December 2020

Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes

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12 December 2020

Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat

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12 December 2020

The pharmacology and mechanism of action of riluzole

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12 December 2020

Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathy

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12 December 2020

Chronic heroin self-administration desensitizes mu opioid receptor-activated G-proteins in specific regions of rat brain.

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12 December 2020

Continuous co-administration of dextromethorphan or MK-801 with morphine: attenuation of morphine dependence and naloxone-reversible attenuation of morphine tolerance

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12 December 2020

The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids

1 reference

12 December 2020

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

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12 December 2020

Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity

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12 December 2020

Changes in the expression of glial glutamate transporters in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal

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12 December 2020

Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance.

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12 December 2020

Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614

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12 December 2020

The development of morphine tolerance and dependence is associated with translocation of protein kinase C.

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12 December 2020

Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system.

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12 December 2020

Hyperalgesia induced by high-dose intrathecal sufentanil in neuropathic pain.

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12 December 2020

The role of NMDA receptors in neonatal cocaine-induced neurotoxicity

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12 December 2020

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

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12 December 2020

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12 December 2020

The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord.

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12 December 2020

Inhibition of morphine tolerance and dependence by MS-153, a glutamate transporter activator

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12 December 2020

Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice

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12 December 2020

Increases in protein kinase C gamma immunoreactivity in the spinal cord of rats associated with tolerance to the analgesic effects of morphine

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12 December 2020

Primary astroglial cultures derived from several rat brain regions differentially express mu, delta and kappa opioid receptor mRNA.

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12 December 2020

Oral administration of dextromethorphan prevents the development of morphine tolerance and dependence in rats

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12 December 2020

Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid

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12 December 2020

Characterization of striatal lesions produced by glutamate uptake alteration: cell death, reactive gliosis, and changes in GLT1 and GADD45 mRNA expression

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12 December 2020

Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study

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12 December 2020

Delayed application of MK-801 attenuates development of morphine tolerance in rats

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12 December 2020

Delta-opioid receptor immunoreactivity on astrocytes is upregulated during mitosis

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12 December 2020

Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion

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12 December 2020

Regulation of the glial Na+-dependent glutamate transporters by cyclic AMP analogs and neurons

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12 December 2020

Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor.

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12 December 2020

Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C.

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12 December 2020

Repeated cocaine alters glutamate receptor subunit levels in the nucleus accumbens and ventral tegmental area of rats that develop behavioral sensitization.

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12 December 2020

Acute decrease in net glutamate uptake during energy deprivation.

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12 December 2020

Dextromethorphan attenuates and reverses analgesic tolerance to morphine

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12 December 2020

Neuronal regulation of glutamate transporter subtype expression in astrocytes.

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12 December 2020

The interleukin-1beta-mediated regulation of proenkephalin and opioid receptor messenger RNA in primary astrocyte-enriched cultures

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12 December 2020

Regulation of the glial glutamate transporter GLT-1 by glutamate and delta-opioid receptor stimulation

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12 December 2020

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12 December 2020

Regional differences in the effects of glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid on extracellular amino acids and dopamine in rat brain: an in vivo microdialysis study

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12 December 2020

NMDA receptor inhibition prevents tolerance to cocaine

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12 December 2020

10.1523/JNEUROSCI.22-18-08312.2002

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DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758088&resulttype=core&format=json

12 May 2020

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12 May 2020

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