Why do nitric oxide synthases use tetrahydrobiopterin? (Q44141020)

30 November 2017

title

Why do nitric oxide synthases use tetrahydrobiopterin? (English)

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30 November 2017

1

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30 November 2017

Zhi-Qiang Wang

2

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30 November 2017

Abigail L Meade

series ordinal

3

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30 November 2017

John F McDonald

series ordinal

4

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30 November 2017

Dennis J Stuehr

series ordinal

5

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30 November 2017

publication date

1 September 2002

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Journal of Inorganic Biochemistry

30 November 2017

published in

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30 November 2017

volume

91

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30 November 2017

issue

4

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30 November 2017

page(s)

618-624

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Nitric oxide synthases: structure, function and inhibition

30 November 2017

cites work

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Catalysis by nitric oxide synthase

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Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase. Characterization of the FMN-FREE enzyme

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7 January 2021

The C termini of constitutive nitric-oxide synthases control electron flow through the flavin and heme domains and affect modulation by calmodulin

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7 January 2021

Purification of a Ca2+/calmodulin-dependent nitric oxide synthase from porcine cerebellum. Cofactor-role of tetrahydrobiopterin

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7 January 2021

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7 January 2021

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Nitric oxide synthases: properties and catalytic mechanism

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X-ray absorption near edge studies of cytochrome P-450-CAM, chloroperoxidase, and myoglobin. Direct evidence for the electron releasing character of a cysteine thiolate proximal ligand

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7 January 2021

The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability

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7 January 2021

Low-Temperature Optical Absorption Spectra Suggest a Redox Role for Tetrahydrobiopterin in Both Steps of Nitric Oxide Synthase Catalysis†

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The Ferrous Dioxygen Complex of the Oxygenase Domain of Neuronal Nitric-oxide Synthase

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Autoxidation rates of neuronal nitric oxide synthase: effects of the substrates, inhibitors, and modulators

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Low-temperature stabilization and spectroscopic characterization of the dioxygen complex of the ferrous neuronal nitric oxide synthase oxygenase domain

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Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

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7 January 2021

Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase

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7 January 2021

Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism

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7 January 2021

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center

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7 January 2021

Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin.

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7 January 2021

Reactivity of tetrahydrobiopterin bound to nitric-oxide synthase

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7 January 2021

The role of tetrahydrobiopterin in the activation of oxygen by nitric-oxide synthase

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7 January 2021

Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase

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7 January 2021

Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen†

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7 January 2021

Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy.

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7 January 2021

Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions

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7 January 2021

Kinetic studies on the successive reaction of neuronal nitric oxide synthase from L-arginine to nitric oxide and L-citrulline

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7 January 2021

Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.

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7 January 2021

Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.

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7 January 2021

A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin

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7 January 2021

Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase

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7 January 2021

Oxygen reduction by nitric-oxide synthases

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7 January 2021

Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.

1 reference

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7 January 2021

Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457

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7 January 2021

A conserved tryptophan 457 modulates the kinetics and extent of N-hydroxy-L-arginine oxidation by inducible nitric-oxide synthase

1 reference

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7 January 2021

10.1016/S0162-0134(02)00432-4

Identifiers

DOI

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30 November 2017

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