Characterization of the Ikappa B-kinase NEMO binding domain (Q44147137)

30 November 2017

Characterization of the Ikappa B-kinase NEMO binding domain (English)

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30 November 2017

Michael J May

1

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author name string

Ralf B Marienfeld

series ordinal

2

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PubMed ID

12244103

30 November 2017

Sankar Ghosh

series ordinal

3

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PubMed ID

12244103

30 November 2017

language of work or name

English

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publication date

19 September 2002

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Journal of Biological Chemistry

30 November 2017

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30 November 2017

277

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30 November 2017

45992-46000

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30 November 2017

48

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The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

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Missing pieces in the NF-kappaB puzzle

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Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

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Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

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The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

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The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression

21 January 2018

1 reference

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Analysis of domains in the IKKalpha and IKKbeta proteins that regulate their kinase activity

21 January 2018

1 reference

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Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

21 January 2018

1 reference

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JNK2 and IKKbeta are required for activating the innate response to viral infection

21 January 2018

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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1 reference

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IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis

21 January 2018

1 reference

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Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

21 January 2018

1 reference

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IKK1-deficient mice exhibit abnormal development of skin and skeleton

21 January 2018

1 reference

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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

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Limb and skin abnormalities in mice lacking IKKalpha

21 January 2018

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IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

21 January 2018

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IkappaB kinase alpha is essential for mature B cell development and function

21 January 2018

1 reference

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

1 reference

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

1 reference

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

1 reference

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IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

21 January 2018

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NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

21 January 2018

1 reference

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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

21 January 2018

1 reference

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Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium

21 January 2018

1 reference

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Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia

21 January 2018

1 reference

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Regulation of the NF-kappaB activation pathway by isolated domains of FIP3/IKKgamma, a component of the IkappaB-alpha kinase complex

21 January 2018

1 reference

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Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex

21 January 2018

1 reference

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Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization

21 January 2018

1 reference

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Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

21 January 2018

1 reference

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The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF

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1 reference

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Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

21 January 2018

1 reference

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Impaired capacity to lose visceral adipose tissue during weight reduction in obese postmenopausal women with the Trp64Arg beta3-adrenoceptor gene variant.

21 January 2018

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

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Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation

21 January 2018

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A hot spot of binding energy in a hormone-receptor interface

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Anatomy of hot spots in protein interfaces

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Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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Identifiers

DOI

10.1074/JBC.M206494200

1 reference

30 November 2017

1 reference

PubMed ID

12244103