Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. (Q44156249)

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13 December 2019

title

Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine (English)

1 reference

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13 December 2019

4

Brian K Kobilka

2 references

30 November 2017

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13 December 2019

author name string

Jenna S Franowicz

1

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13 December 2019

Lynn E Kessler

2

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13 December 2019

Catherine M Dailey Borja

3

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13 December 2019

Lee E Limbird

5

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13 December 2019

Amy F T Arnsten

6

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13 December 2019

language of work or name

English

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publication date

1 October 2002

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13 December 2019

published in

Journal of Neuroscience

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13 December 2019

volume

22

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13 December 2019

page(s)

8771-8777

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13 December 2019

issue

19

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The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes.

13 December 2019

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An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder

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The alpha-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys.

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Effects of guanfacine on three forms of distraction in the aging macaque.

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Alteration of brain noradrenergic activity in rhesus monkeys affects the alerting component of covert orienting.

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Behavioral and receptor binding analysis of the α2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-YL amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an α2-adrenoceptor subtype

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Prefrontal neuronal activity in rhesus monkeys performing a delayed anti-saccade task.

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12 December 2020

Effects of medetomidine, an alpha-2 adrenoceptor agonist, and atipamezole, an alpha-2 antagonist, on spatial memory performance in adult and aged rats

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Overexpression of alpha2C-adrenoceptors impairs water maze navigation.

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12 December 2020

Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys.

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12 December 2020

Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

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12 December 2020

Local infusion of an alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys.

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Guanfacine for PTSD nightmares

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The alpha-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys.

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12 December 2020

Delineation of rat kidney α2A- and α2B-adrenoeeptors with [3H]RX821002 radiollgand binding: computer modelling reveals that guanfacine is an α2A-selective compound

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12 December 2020

Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

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Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence

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12 December 2020

Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.

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12 December 2020

Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys.

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12 December 2020

Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates.

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12 December 2020

The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats.

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12 December 2020

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12 December 2020

The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task.

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12 December 2020

Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels.

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12 December 2020

Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys

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12 December 2020

Guanfacine, but not clonidine, improves planning and working memory performance in humans

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12 December 2020

Clonidine enhances delayed matching-to-sample performance by young and aged monkeys

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12 December 2020

Role of alpha2C-adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the alpha2C-adrenoceptor gene.

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12 December 2020

Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task

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12 December 2020

10.1523/JNEUROSCI.22-19-08771.2002

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13 December 2019

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