Conformational behavior of human alpha-synuclein is modulated by familial Parkinson's disease point mutations A30P and A53T. (Q44214168)

30 November 2017

Conformational behavior of human alpha-synuclein is modulated by familial Parkinson's disease point mutations A30P and A53T. (English)

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30 November 2017

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2

Vladimir N Uversky

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30 November 2017

Jie Li

1

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PubMed ID

12428728

30 November 2017

Anthony L Fink

series ordinal

3

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30 November 2017

1 October 2002

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30 November 2017

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30 November 2017

23

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30 November 2017

4-5

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30 November 2017

553-567

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Aluminum-containing antacids as a cause of idiopathic Parkinson's disease

30 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Synthetic filaments assembled from C-terminally truncated alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

A Drosophila model of Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Protein aggregation: folding aggregates, inclusion bodies and amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Neuropathology of Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

The awakening of α-synuclein

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Treatment of Parkinson's disease in 'Ayurveda' (ancient Indian system of medicine): discussion paper

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

A case-control study of Parkinson's disease in a horticultural region of British Columbia

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Aggregation of chymotrypsinogen: portrait by infrared spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Identification of two distinct synucleins from human brain

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Aggregation of recombinant human interferon gamma: kinetics and structural transitions

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Pesticides and Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Studies of the structure of insulin fibrils by Fourier transform infrared (FTIR) spectroscopy and electron microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

A new attenuated total reflectance Fourier transform infrared spectroscopy method for the study of proteins in solution

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Nativelike secondary structure in interleukin-1 beta inclusion bodies by attenuated total reflectance FTIR.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Secondary structure characterization of beta-lactamase inclusion bodies.

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Alpha-synuclein in Lewy bodies

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7 January 2021

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

The role of environmental toxins in the etiology of Parkinson's disease

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7 January 2021

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

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7 January 2021

Association-induced folding of globular proteins

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7 January 2021

Association of partially-folded intermediates of staphylococcal nuclease induces structure and stability

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

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https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0161-813X%2802%2900066-9

7 January 2021

10.1016/S0161-813X(02)00066-9

Identifiers

DOI

1 reference

30 November 2017

1 reference

PubMed ID

12428728